Safety and effectiveness of GLP-1 receptor agonists and SGLT inhibitors added to insulin in adults with type 1 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, registry-based study will observe adults with type 1 diabetes who are already prescribed GLP-1RA or SGLT inhibitors in addition to insulin. Data from patients using continuous glucose monitoring will be collected for at least one month before enrollment and throughout the study to evaluate safety and potential efficacy. The analysis will focus on real-world outcomes, including glycemic control and adverse events, in a non-interventional setting. Leading institutions in Indiana, California, and Florida will collaborate with the Jaeb Center to aggregate data across sites. The study does not specify a formal intervention beyond usual care adjunct therapies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ≥18 years of age
* Clinical diagnosis of T1D
* GLP-1RA or SGLTi (SGLT-1 and SGLT-2 inhibitors) drug prescribed by their provider for any indication as part of usual care with use for no more than 1 week
* Use of CGM and availability of CGM data for 1 month prior to enrollment and expected to be available throughout the study
* Willing and able to provide informed consent

Exclusion Criteria:

* No exclusion criteria other than those not meeting inclusion criteria above

Where it's running

• Hoag Memorial Hospital
  Newport Beach, California, United States Recruiting
• University of California, San Francisco (UCSF)
  San Francisco, California, United States Recruiting
• University of Miami
  Miami, Florida, United States Recruiting
• Emory University
  Atlanta, Georgia, United States Recruiting
• Northwestern University
  Chicago, Illinois, United States Recruiting
• University of Louisville
  Louisville, Kentucky, United States Recruiting

Study contacts

• Study coordinator: Kanchan Bhasin, MBBS, MS
• Email: kanbhas@iu.edu
• Phone: (317)-278-2752

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.