Sacubitril/valsartan after bypass to treat moderate ischemic mitral regurgitation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, controlled trial testing sacubitril/valsartan (an angiotensin receptor–neprilysin inhibitor) given after isolated CABG in patients with moderate ischemic mitral regurgitation. Patients are enrolled if they had moderate IMR confirmed on two consecutive preoperative transthoracic echocardiograms and meet safety labs and blood pressure criteria. The main outcome is change in mitral regurgitation severity and related cardiac remodeling measured by echocardiography over follow-up. Key exclusions include symptomatic hypotension, severe renal dysfunction, high serum potassium, history of angioedema with RAAS blockers, or concurrent mitral valve interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Fully informed and voluntarily signed informed consent;
2. Received CABG and moderate IMR was diagnosed on two consecutive preoperative transthoracic echocardiography (according to 2021 ESC/EACTS Guidance Standards )

Exclusion Criteria:

1.Symptomatic hypotension and/or a SBP \< 100 mmHg at screening; 2.Estimated GFR \< 30 mL/min/1.73m2; 3.Serum potassium \> 5 mmol/L at screening; 4.History of angioedema or unacceptable side effects while receiving ACE inhibitors or ARBs; 5.Patients receiving mitral valve intervention at the same time, or have participated in other clinical trials, or are unwilling to participate in this study.

Where it's running

• China National Center for Cardiovascular Diseases
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Lianxin Chen, M.D.
• Email: chenlianx1@163.com
• Phone: 010-88322265

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.