Ruscus for symptom control in uncomplicated chronic venous disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, prospective observational study collects real-world data on the use of Ruscus aculeatus in adults with CEAP C1-C6 chronic venous disease. Participants are treated at the discretion of their physicians, with follow-up visits at baseline, day 30, and day 90 to assess symptoms, quality of life, adherence, and safety. Outcomes include changes in the revised Venous Clinical Severity Score (rVCSS), pain by VAS, CIVIQ-20 quality of life, and adverse events. No study-mandated interventions are imposed beyond routine care. The study aims to describe how Ruscus aculeatus performs in everyday clinical practice and its safety profile in a real-world setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 to 75 years.
* Patients prescribed Ruscus aculeatus L. as part of routine clinical practice, with the baseline visit performed within 7 days after treatment initiation.
* Symptomatic chronic venous disease classified as CEAP (2020) C1-C6.
* Willing and able to provide written informed consent and complete study as sessments.

Exclusion Criteria:

* Symptomatic patients classified as CEAP C0.
* Uncontrolled hypertension.
* Lower extremity dermatitis or ulcer related to peripheral arterial disease or diabetes.
* Neurological or orthopedic conditions limiting mobility or independent walking.
* Active systemic infection.
* Known malignancy or ongoing chemotherapy.
* Acute deep vein thrombosis or acute superficial vein thrombosis.
* Cognitive or physical conditions preventing participation in routine follow-up visits.
* Pregnant or breastfeeding women.

Where it's running

• Ankara Training and Research Hospital
  Ankara, Ankara, Turkey (Türkiye) Recruiting
• Ankara University Faculty of Medicine Hospital
  Ankara, Ankara, Turkey (Türkiye) Recruiting
• Bilkent City Hospital
  Ankara, Ankara, Turkey (Türkiye) Recruiting
• Etlik City Hospital
  Ankara, Ankara, Turkey (Türkiye) Recruiting
• SBU Gulhane Training and Research Hospital
  Ankara, Ankara, Turkey (Türkiye) Recruiting
• SBU Sincan Training and Research Hospital
  Ankara, Ankara, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Nevzate Erdil, MD — Antalya City Hospital
• Study coordinator: Nevzat Erdil, MD
• Email: nevzatkutay@gmail.com
• Phone: +90 532 427 18 20

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.