rTMS to improve BCI control for upper‑limb rehabilitation after chronic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial enrolls adults with chronic single‑stroke upper‑limb motor deficits and visible finger extension to receive repeated transcranial magnetic stimulation combined with BCI‑guided motor training. Treatments are delivered at the Institut du Cerveau in Paris over multiple sessions while researchers record BCI control and clinical motor scores. Outcomes include changes in upper‑extremity Fugl‑Meyer scores and BCI performance measures to link physiological effects with functional gains. The protocol excludes patients with severe spasticity, major comprehension deficits, degenerative neurological disease, or skin/scalp lesions that prevent EEG or stimulation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Single Stroke older than 6 months
* Distal motor deficit of the upper limb (UE-FMA score \< 53) with visible extension of the fingers (Medical Research Council (mRC) score ≥ 2)
* Right-handed
* Between 18 and 85 years of age
* Having given their written consent

Exclusion Criteria:

* Patient under tutorship or guardianship, under safeguard of justice, deprived of liberty, pregnant or breast feeding women
* Life-threatening pathologies or compromising follow-up during the study period
* Trouble of understanding : score below 12/15 in the Boston Diagnostic Aphasia Examination (BDAE) order execution test
* Fixed spasticity of finger or carpal flexors (mAS score = 4) or botulinum toxin injection less than 12 weeks old in the forearm or hand
* History of degenarative neurological pathology or craniectomy
* Deficient upper limb skin lesion preventing use of mucle stimulation
* Skin lesion of the scalp preventing EEG placement
* Participation in biomedical therapeutic research that may affect the recovery of the deficient hand during the study
* Patient who has previously participated in a therapeutic study rTMS (excluding single shock) or a BCI
* Patient who does not wish to be informed of a brain abnormality discovered accidentally on MRI

Where it's running

• Institut du Cerveau
  Paris, France Recruiting

Study contacts

• Study coordinator: Paolo BARTOLOMEO, MD, INSERM DR2
• Email: paolo.bartolomeo@upmc.fr
• Phone: +33 1 57 27 41 40

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.