ROS-scavenging nanoenzyme prevention for radiation dermatitis in head and neck cancer
Official title: Novel ROS-scavenging Nanoenzymes for the Treatment of Radiation Dermatitis in Patients With Head and Neck Cancer
Run by West China Hospital · NCT07064577 · Data updated 2026-11-12
This trial will try to see if giving novel ROS-scavenging nanoenzymes can prevent radiation-related skin damage in people receiving high-dose radiotherapy for head and neck cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | West China Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Chengdu, Sichuan) |
| Status | Recruiting |
| Started | July 15, 2025 |
| Main results expected | September 15, 2025 |
| Study ends | October 15, 2025 |
| Registry record updated | August 7, 2025 |
| Trial ID | NCT07064577 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with non-metastatic head and neck malignancies who are scheduled for high-dose radiotherapy (primary or postoperative), have ECOG performance status ≤2, and have no prior head and neck radiotherapy or active skin lesions in the treatment area.
✕Probably not a fit
People with prior head and neck radiotherapy, preexisting skin ulcers or rashes in the treatment area, inflammatory or connective tissue skin disorders, poor performance status (ECOG >2), or metastatic disease are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Radiotherapy for head and neck cancer commonly causes radiation dermatitis, which can affect appearance and sometimes require treatment breaks. This interventional study will give novel ROS-scavenging nanoenzymes alongside standard care and compare outcomes with standard care alone to see if dermatitis can be prevented. Key outcomes include the incidence and severity of skin reactions during radiotherapy and short-term follow-up. Eligible participants are adults with non-metastatic head and neck cancer planned for high-dose radiotherapy and without prior head and neck radiation or active skin disease in the treatment area.
Why it matters
Potential benefit: If successful, the nanoenzymes could reduce how often and how severely radiation dermatitis occurs and help prevent interruptions to cancer treatment.
How similar studies have gone: Some topical and antioxidant approaches for radiation dermatitis have shown mixed or limited benefit, and ROS-scavenging nanoenzymes represent a novel approach with little prior clinical evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with a pathological diagnosis of non-metastatic head and neck malignant tumors; 2. Patients deemed suitable for high-dose radiotherapy, either as a primary treatment or as postoperative treatment following surgical resection. Exclusion Criteria: 1. Eastern Cooperative Oncology Group performance status of \>2; 2. Pre-existing skin rash, ulceration or open wound in the treatment area; 3. Inflammatory or connective tissue disorder of the skin; 4. History of head and neck radiotherapy.
Where it's running
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West China Hospital, Sichuan University
Chengdu, Sichuan, China Recruiting
Study contacts
- Principal investigator: Xingchen Peng, Prof. — Sichuan University West China Hospital
- Study coordinator: Xingchen Peng, Prof.
- Email: pxx2014@163.com
- Phone: +86 18980606753
Similar studies
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Amino acid–derived antioxidant lipids to prevent and treat radiation skin damage in head and neck cancer
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.