Robotic knee replacement tailored for varus (bow-legged) knees

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with unilateral, advanced varus knee osteoarthritis will receive total knee arthroplasty performed with an active robotic surgical system, with alignment decisions informed by multislice CT and weight-bearing (vertical) CT comparisons to the opposite limb. The study will quantify physiological versus pathological varus under load and use those measurements to guide mechanical or kinematic alignment choices. Investigators will develop an algorithm for selecting alignment strategy based on the degree of varus deformity and follow patients for 12 months after surgery. Outcomes will focus on limb alignment, pain, and functional recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients over 18 years of age with grade 3-4 knee osteoarthritis (according to Kellgren-Lawrence) and pain score of 5 or higher on a 10-point VAS scale.
2. Varus deformity of the lower limb (HKA angle \<177°, or varus \>3°)
3. Anesthesia risk according to the ASA scale of no more than III.
4. BMI less than 35 kg/m2.
5. Patient must be monitored throughout the entire study period (12 months).
6. Patient must be mentally competent and compliant.
7. Patient must provide written informed consent to participate in the study.

Exclusion Criteria:

1. Body mass index \> 40 kg/m².
2. Instability of the collateral ligaments of the knee joint requiring the installation of ligamentous systems, presence of primary severe bone defects.
3. Impaired weight-bearing ability of the contralateral limb.
4. Presence of metal implants or foreign bodies in the lower extremities.
5. Previous knee interventions, such as reconstruction of the knee ligament apparatus, or corrective osteotomies of the femur and tibia.
6. Patient refusal to participate in the study.
7. Patient failure to comply with the recommendations of the treating physician or the prescribed regimen.

Where it's running

• University clinical hospital №1 I.M.Sechenov First Moscow State Medical University. The Department of Traumatology, Orthopedics and Disaster Surgery
  Moscow, Russia Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effects of virtual reality on walking in adults with knee osteoarthritis

  This study tests how immersive virtual reality environments—designed to feel safe or to provoke fear—affect walking and worry about movement in adults 50 and older with knee osteoarthritis and in healthy peers.

  Recruiting University of Primorska · Vilnius and 1 other locations · NCT07920120

• Weekly berobenatide for knee osteoarthritis in adults who are overweight or obese

  This study tests whether weekly berobenatide helps reduce knee pain and improve function, while also affecting body weight, in adults with knee osteoarthritis who are overweight or obese (with or without type 2 diabetes).

  Recruiting Phase 3 Pfizer · Birmingham, Alabama and 3 other locations · NCT07915609

• Autologous adipose-derived stem cell injections for knee osteoarthritis

  We’re testing whether injecting a patient’s own fat-derived stem cells into the knee can help people with knee OA feel less pain and move better, compared with a standard hyaluronic acid treatment.

  Recruiting at 3 sites Yonsei University · Incheon and 2 other locations · NCT07901790

• Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty

  This study tests whether higher burden of preoperative multimorbidity affects functional recovery after knee replacement in adults with knee osteoarthritis.

  Recruiting Balikesir Ataturk City Hospital · Balıkesir · NCT07882316

• Cartilage biomarker response to acute loading in knee OA by antiresorptive treatment status

  Researchers will test whether a 30-minute treadmill walk changes cartilage biomarkers in postmenopausal women with knee osteoarthritis, comparing those on denosumab, bisphosphonates, and those not on antiresorptives.

  Recruiting Sisli Hamidiye Etfal Training and Research Hospital · Istanbul, Istanbul · NCT07881861

• Lysyl Enzymes in Knee Osteoarthritis

  This study tests whether blood levels of lysyl hydroxylase and lysyl oxidase differ between people with knee osteoarthritis and healthy individuals.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar · NCT07875296

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.