Robotic bronchoscopy with moderate propofol sedation
Robotic-assisted Bronchoscopy Under Moderate Sedation With Propofol: A Single-center Pilot Study.
This pilot test will see if robotic bronchoscopy works safely and comfortably with moderate sedation using propofol for adults who need lung biopsies.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Zurich Academic / other |
| Locations | 1 site (Zurich, Canton of Zurich) |
| Trial ID | NCT07006311 on ClinicalTrials.gov |
What this trial studies
This single-center pilot enrolls adults undergoing transbronchial biopsy for lung lesions to receive robotic-assisted bronchoscopy under moderate sedation with propofol. Participants who meet inclusion criteria and provide consent will have the procedure with tracheal intubation as planned. The team will collect feasibility and safety data, including procedure completion, sedation tolerance, and any complications. Findings will inform whether a larger, comparative trial is warranted.
Who should consider this trial
Good fit: Adults (18+) scheduled for bronchoscopy with planned transbronchial biopsy who can give informed consent and are planned for moderate sedation with tracheal intubation are the ideal candidates.
Not a fit: Patients with endobronchial lesions causing lobar atelectasis, severe cardiopulmonary disease, coagulation disorders, pregnancy or lactation, or other contraindications to bronchoscopy or anesthesia are unlikely to benefit.
Why it matters
Potential benefit: If successful, this could allow patients to have robotic bronchoscopy without general anesthesia, reducing procedure burden and potentially increasing access to advanced diagnostic bronchoscopy.
How similar studies have performed: Robotic bronchoscopy has demonstrated feasibility and diagnostic yield in prior studies under general anesthesia, but performing it under moderate sedation with propofol is relatively novel and not widely reported.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * informed consent signed by the subject * aged at least 18 years * scheduled for bronchoscopy with moderate sedation and tracheal intubation in order to obtain at least 1 specimens of the lung via transbronchial biopsy * necessary periinterventional laboratory examinations needed for the bronchoscopy * judgement of the subject Exclusion Criteria: * endobronchial lesion causing lobar atelectasis * inability or contraindications to undergo bronchoscopy (e.g. severe cardiopulmonary diseases, coagulation disorders, intolerance to anesthesia or endoscopic operation, psychiatric disorders or severe neurosis) * pregnant or lactating women
Where this trial is running
Zurich, Canton of Zurich
- University Hospital Zurich — Zurich, Canton of Zurich, Switzerland (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.