Robot-assisted versus endoscopic breast-conserving surgery for breast cancer
Official title: A Retrospective Analysis of Robot-Assisted Versus Endoscopic Breast-Conserving Surgery for Breast Cancer
Run by Sixth Affiliated Hospital, Sun Yat-sen University · NCT07321145 · Data updated 2026-11-12
This test compares robot-assisted and endoscopic breast-conserving surgery in women with a single breast tumor who want to keep their breast, to see which approach gives better surgical and cosmetic results.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | Women only |
| Enrollment | 200 (estimated) |
| Sponsor | Sixth Affiliated Hospital, Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | June 27, 2025 |
| Main results expected | May 31, 2026 |
| Study ends | May 31, 2026 |
| Registry record updated | January 6, 2026 |
| Trial ID | NCT07321145 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–80 with pathologically confirmed unifocal breast cancer, tumor-to-breast volume ratio ≤20%, desire for breast conservation, no distant metastasis, and eligibility for standard postoperative radiotherapy are ideal candidates.
✕Probably not a fit
Patients with diffuse lesions or microcalcifications unlikely to achieve clear margins, bilateral or inflammatory breast cancer, prior chest irradiation, pregnancy- or lactation-associated cancer, or inability to tolerate general anesthesia are unlikely to benefit from these techniques.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center retrospective comparison of patients who underwent robot-assisted breast-conserving surgery (RABCS) or endoscopic breast-conserving surgery (E-BCS) at the Sixth Affiliated Hospital of Sun Yat-sen University. The analysis examines operative metrics, margin status, complications, and cosmetic outcomes in women with unifocal breast cancer and a tumor-to-breast volume ratio ≤20%. The protocol highlights robotic system advantages such as enhanced dexterity, a magnified three-dimensional high-definition view, and high-resolution imaging that may improve precision in the confined operative space of the breast. Being a retrospective, single-center analysis, results will reflect local surgical expertise and patient selection and will help define areas for future prospective study.
Why it matters
Potential benefit: If successful, the comparison could show that robot-assisted surgery provides improved precision and cosmetic outcomes with similar or lower complication rates, supporting broader adoption for selected patients.
How similar studies have gone: Small case series and single-center reports have shown the feasibility and favorable cosmetic results of robotic breast surgery, but high-quality comparative and long-term outcome data remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged 18 to 80 years * Pathologically confirmed breast cancer prior to surgery * Sufficient glandular volume with a tumor-to-breast volume ratio ≤20% * A unifocal lesion confined to the glandular tissue * Clear desire for breast conservation and willingness to undergo R-BCS or E-BCS * No evidence of distant metastasis, no involvement of the skin or chest wall * Eligibility for standard postoperative radiotherapy Exclusion Criteria: * The presence of diffuse suspicious lesions or microcalcifications for which wide local resection was unlikely to achieve adequate negative margins or satisfactory aesthetic outcomes * Bilateral breast cancer or inflammatory breast cancer * After neoadjuvant therapy, requirement for additional concurrent surgical procedures * Inability to tolerate general anesthesia or undergo surgery * Contraindications to radiotherapy or a history of prior chest wall irradiation, pregnancy- or lactation-associated breast cancer * Refuse to undergo R-BCS or E-BCS
Where it's running
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the Sixth Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: Haiyan Li
- Email: lihy27@mail.sysu.edu.cn
- Phone: +86 15813340604
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.