RNA sequencing of removed tracheal tissue to characterize scarring in tracheal and subglottic stenosis
RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis
This project will test whether RNA sequencing of tissue removed from people with benign tracheal or subglottic stenosis can reveal molecular patterns that explain the scarring.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT07258784 on ClinicalTrials.gov |
What this trial studies
This observational project collects tissue that would otherwise be discarded during routine biopsies or surgical resections in patients with benign tracheal or subglottic stenosis. Researchers will perform RNA sequencing to profile gene expression and define disease-specific molecular signatures. Patients with malignancy or active infection are excluded, and clinical care is not altered by participation. The aim is to map cellular and inflammatory pathways involved in fibroinflammatory airway narrowing to inform future diagnostics and therapies.
Who should consider this trial
Good fit: Ideal candidates are people with benign tracheal or subglottic stenosis who are undergoing biopsy or surgical resection and do not have active infection or cancer.
Not a fit: Patients with malignant airway disease, active infections, or those not scheduled for tissue biopsy or resection are not eligible and would not benefit from this research.
Why it matters
Potential benefit: If successful, the findings could identify biomarkers or molecular targets that lead to improved diagnosis or new treatments for benign tracheal stenosis.
How similar studies have performed: RNA sequencing has successfully revealed disease mechanisms in other fibrotic and inflammatory airway conditions, but applying it specifically to benign tracheal stenosis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with benign tracheal stenosis Exclusion Criteria: * Malignancy. active infection
Where this trial is running
Baltimore, Maryland
- University of Maryland — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Study coordinator: Chenchen Zhang, MD
- Email: chenchen.zhang@som.umaryland.edu
- Phone: 14103288141
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.