Ripening Approaches for Prompt Induction and Delivery: Sequential vs. Combined Cervical Ripening in First-Time Moms
Official title: Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)
Run by Ochsner Health System · NCT07717502 · Data updated 2026-11-12
This study tests whether a sequential or a combined method of cervical ripening helps first-time moms deliver vaginally within 24 hours during labor induction.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 260 (estimated) |
| Sponsor | Ochsner Health System Academic / other |
| Locations | 1 site (New Orleans, Louisiana) |
| Status | Recruiting |
| Started | August 18, 2026 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | August 24, 2026 |
| Trial ID | NCT07717502 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Nulliparous women with singleton, vertex pregnancies at term who are eligible for outpatient cervical ripening and meet local eligibility criteria.
✕Probably not a fit
Women with uterine scars, prior full-thickness procedures, placental abnormalities, or other high-risk factors may not benefit from these strategies.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial compares two multimodal cervical ripening strategies in nulliparous women at term undergoing induction of labor. It aims to determine which approach more effectively achieves vaginal delivery within 24 hours. Interventions involve sequential cervical ripening versus inpatient combined cervical ripening with Dilapan-S devices and misoprostol. Eligible participants are nulliparous, carrying singleton, vertex pregnancies at term who may be candidates for outpatient ripening. The study is led by Ochsner Health System with Medicem International as collaborators at Ochsner Baptist in New Orleans.
Why it matters
Potential benefit: If successful, the approach could shorten labor time and increase chances of vaginal delivery for first-time moms undergoing induction.
How similar studies have gone: Previous studies in cervical ripening have shown varying success with multimodal strategies; this trial tests a direct comparison between sequential and combined methods in a specific population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Nulliparous patients with singleton pregnancies with vertex lie at term receiving prenatal care that are eligible for outpatient cervical ripening will be eligible Exclusion Criteria: * age less than 18, * suspected major fetal anomalies (including suspected or proven chromosome anomalies, congenital cardiac disease expected to require neonatal intervention, and multiple anomalies suggestive of a complex syndrome), * fetal growth restriction * oligohydramnios * prior full thickness * uterine scar * placenta previa, * low-lying placenta, * premature rupture of amniotic membranes, * cervical dilation \> 2 cm * modified Bishop score \> 4 * residence greater than 60 minutes from the hospital
Where it's running
-
Ochsner Baptist
New Orleans, Louisiana, United States Recruiting
Study contacts
- Study coordinator: Frank Williams, MD
- Email: frank.williams2@ochsner.org
- Phone: 205-994-4820
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Pregnant Women Living with HIV on Bictegravir/Emtricitabine/Tenofovir Alafenamide
This study looks at how B/F/TAF is used in pregnant women with HIV and whether it helps maintain viral suppression from before conception through delivery.
-
Pelvic Floor Training and a Modified Lumbopelvic Belt for Symphysis Pubis Pain in Pregnancy
This study tests whether pelvic floor muscle training plus a modified lumbopelvic belt can reduce pain and improve function for pregnant women with symphysis pubis pain.
-
Effective Communication in VBAC Counseling
This study tests how clearly doctors and midwives explain VBAC options during prenatal visits and whether patients feel understood.
-
Innovative Multidisciplinary and Virtual Care for IBD in Pregnancy
This study tests a dedicated IBD pregnancy care model, including a new virtual approach, to see if it improves access and quality of care for pregnant people with Crohn's disease or ulcerative colitis.
-
Compare spinal-epidural versus general anesthesia for babies after cesarean delivery
This trial tests whether the type of anesthesia used for cesarean delivery affects newborn hearing in babies.
-
Pregnant women weight-management support via an app and care model
Aims to try a smartphone-based weight-management program plus professional support for pregnant women to see if it helps manage gestational weight and promote healthy behaviors.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.