Right-heart ultrasound to predict success of removing the breathing tube in ICU patients
Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit: A Prospective Observational Study
This study will try to see if bedside right-ventricle ultrasound measurements (like TAPSE) can predict whether adult ICU patients on mechanical ventilation will stay off the breathing tube after extubation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Kanuni Sultan Suleyman Training and Research Hospital Academic / other |
| Locations | 1 site (Istanbul, Istanbul) |
| Trial ID | NCT07073976 on ClinicalTrials.gov |
What this trial studies
This is a prospective, observational single-center study in adult ICU patients planned for weaning from mechanical ventilation. Bedside transthoracic echocardiography will be performed within two hours after patients meet clinical weaning criteria to measure TAPSE, tricuspid S', RV-FAC, right atrial area, and pulmonary valve acceleration time. Patients will be followed for 24 hours after extubation to record reintubation, need for noninvasive ventilation or high-flow oxygen, and other respiratory/physiologic data. Demographic and clinical variables (APACHE II, SOFA, ventilation settings, duration of ventilation) will be collected to relate cardiac measurements to weaning outcomes.
Who should consider this trial
Good fit: Adult ICU patients receiving invasive mechanical ventilation who are hemodynamically stable, meet standard clinical weaning criteria, can undergo transthoracic echocardiography within two hours before extubation, and provide informed consent are ideal candidates.
Not a fit: Patients with inadequate acoustic windows, severe tricuspid or congenital valve disease, on extracorporeal life support, with acute pulmonary embolism or cor pulmonale, those requiring urgent/unplanned extubation, or pregnant patients are unlikely to benefit from the protocol.
Why it matters
Potential benefit: If successful, the approach could help clinicians identify patients at higher risk of failed extubation and tailor weaning decisions to reduce reintubation and complications.
How similar studies have performed: Prior observational studies have linked right ventricular dysfunction and measures like TAPSE to weaning failure, but results are mixed and prospective single-center validation remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Receiving invasive mechanical ventilation in the ICU * Planned extubation (weaning) according to standard clinical criteria * Hemodynamically stable at the time of transthoracic echocardiography (TTE) * Ability to undergo echocardiographic assessment within 2 hours prior to extubation * Informed consent obtained from patient or legal representative Exclusion Criteria: * Known severe tricuspid valve disease or congenital heart disease * Moderate to severe pericardial effusion or cardiac tamponade * Inadequate acoustic window for transthoracic echocardiography * Patients requiring urgent or unplanned extubation * Use of extracorporeal life support (e.g., ECMO) at the time of assessment * Known pulmonary embolism or acute cor pulmonale * Pregnancy
Where this trial is running
Istanbul, Istanbul
- Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital — Istanbul, Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Engin ihsan Turan, principal investigator
- Email: enginihsan@hotmail.com
- Phone: +905382431114
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.