Retraining the brain for treating persistent COVID symptoms

Retraining of the Amygdala and Insula for the Treatment of Persistent Covid

Not applicable Interventional Hospital Miguel Servet · NCT05956405

This study is testing a new way to help people with lingering COVID symptoms, like fatigue and mood changes, by using brain training and mindfulness techniques to see if it can improve their mental health and overall well-being.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment100 (estimated)
Ages18 Years and up
SexAll
SponsorHospital Miguel Servet Academic / other
Locations1 site (Zaragoza)
Trial IDNCT05956405 on ClinicalTrials.gov

What this trial studies

This clinical trial focuses on patients suffering from persistent COVID symptoms, which can include fatigue, mood changes, and cognitive difficulties. The approach involves a combination of amygdala-insula training and mindfulness techniques to help reduce over-sensitization and improve mental health outcomes. Participants will engage in specific interventions designed to enhance their psychological well-being and physical function. The study aims to assess the effectiveness of these interventions in alleviating the symptoms associated with prolonged COVID.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals aged 18-30 who have been diagnosed with persistent COVID by their primary care physician.

Not a fit: Patients under 18 years old or those with serious medical or psychiatric illnesses may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly improve the quality of life for patients experiencing persistent COVID symptoms.

How similar studies have performed: While the specific approach of amygdala-insula training for persistent COVID is novel, psychological therapies like mindfulness have shown success in treating similar conditions.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age: 18-30 years old.
* Grant informed consent.
* Diagnosis of persistent COVID by primary care physicians.

Exclusion Criteria:

* Age: \<18 years old
* Serious medical or psychiatric illnesses

Where this trial is running

Zaragoza

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Mental Health Wellness
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.