Respiratory infections in newborns and children up to five years
Official title: Respiratory Infections in Young Children in Colombia and Panamá: Epidemiology, Interactions, and Long-term Consequences.
Run by Centro de Estudios en Infectogía Pediatrica · NCT07249996 · Data updated 2026-11-12
This project will follow newborns in Colombia and Panamá through age five to see how often respiratory infections happen, which germs cause them, and how those infections affect long-term lung health.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 29 Days |
| Sex | All |
| Enrollment | 1088 (estimated) |
| Sponsor | Centro de Estudios en Infectogía Pediatrica Academic / other |
| Locations | 2 sites (Cali, Valle del Cauca Department and 1 other locations) |
| Status | Recruiting |
| Started | May 2, 2024 |
| Main results expected | May 2, 2031 |
| Study ends | December 30, 2031 |
| Registry record updated | November 25, 2025 |
| Trial ID | NCT07249996 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Newborns younger than 29 days whose parent or guardian can give informed consent, remain reachable by phone, and do not plan to relocate from the study area are ideal candidates.
✕Probably not a fit
Infants who cannot be reached by phone, intend to move away from the study locations, are older than the 29-day enrollment window, or who need experimental treatments are unlikely to benefit directly from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multicenter prospective birth cohort that enrolls newborns and follows them until age five to define the frequency, causes, severity, and long-term consequences of respiratory tract infections. Families are contacted twice weekly via a phone app or calls for active surveillance, with in-person visits during infection episodes and routine checkups every six months in the first two years and then continuing through age five. Respiratory specimens and clinical data are collected to identify viral and bacterial pathogens, study interactions between microbes, and measure immune responses and health outcomes over time. The study is observational and does not provide experimental treatments.
Why it matters
Potential benefit: If successful, the findings could help prevent and better manage respiratory infections in young children by identifying common causes, risk factors for severe disease, and immune patterns linked to later lung health.
How similar studies have gone: Previous birth cohort studies have successfully defined viral causes of early-childhood RTIs, but community-based longitudinal cohorts in Latin America are limited, so this study builds on known methods while filling a regional evidence gap.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Newborns younger than 29 days of life, with or without pre-existing conditions * Infants whose parent(s) or guardian(s) are available for telephone contact for the duration of the study, and do not intend to relocate outside of the study area, to ensure adherence to RTI and in-person visits. * Infants whose parent(s) or guardian(s) provide informed consent to participate in the study. * Infants whose parent(s) or guardian(s) are willing to authorize data and specimen collection, storage and analysis. Exclusion Criteria: * Infants born to a pregnant mother under 14 years of age (under Colombian law, pregnancies occurring in individuals younger than 14 years of age are legally presumed to result from sexual abuse).
Where it's running
-
Centro de Estudios en Infectologia Pediatrica, CEIP
Cali, Valle del Cauca Department, Colombia Recruiting -
Cevaxin
Panama City, Panama Recruiting
Study contacts
- Principal investigator: Eduardo Lopez-Medina, MD, MSc — Centro de Estudios en Infectologia Pediatrica, CEIP
- Study coordinator: Eduardo Lopez-Medina, MD, MSc
- Email: eduardo.lopez@ceiponline.org
- Phone: +57 315 0467762
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.