Research sample repository for blood and cellular therapies
Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries
This study is collecting blood samples to help researchers learn more about how to improve outcomes for people receiving blood and cell therapies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 99999999 (estimated) |
| Sex | All |
| Sponsor | Center for International Blood and Marrow Transplant Research Research network |
| Drugs / interventions | Radiation |
| Locations | 1 site (New Brighton, Minnesota) |
| Trial ID | NCT04920474 on ClinicalTrials.gov |
What this trial studies
This research sample repository aims to collect and provide access to blood samples for studies related to hematopoietic cell transplantation and other cellular therapies. It allows researchers to investigate factors affecting transplant outcomes, analyze genomic data, and study the distribution of HLA tissue types across populations. The repository will accept samples from donors, cord blood units, recipients of cellular therapies, and patients with marrow toxic injuries. This initiative supports anonymous research to enhance understanding and treatment of related conditions.
Who should consider this trial
Good fit: Ideal candidates include donors of hematopoietic cells, recipients of cellular therapies, and patients with marrow toxic injuries.
Not a fit: Patients who are not involved in hematopoietic cell transplantation or do not have marrow toxic injuries may not benefit from this study.
Why it matters
Potential benefit: If successful, this repository could significantly improve the understanding and outcomes of hematopoietic cell transplantation and cellular therapies.
How similar studies have performed: Other studies utilizing sample repositories for cellular therapies have shown promise, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Eligibility to participate in the Research Sample Repository Protocol: Hematopoietic Cell (HC) or Other Cellular Therapy Donors * Donors are eligible to participate in the Research Sample Repository if they have donated or are scheduled to donate HCs or cellular therapy products to an allogeneic recipient either by a marrow harvest or by apheresis. This includes adults with and without decision making capacity and children. * All donors registered on the National Marrow Donor Program (NMDP) Registry, regardless of whether they have been requested to donate a product for a patient, are eligible to participate in the Research Sample Repository. Cord Blood Units (CBUs) * Testable material from CBUs (Specimens) infused at treatment centers covered under the C. W. Bill Young Transplantation Program are eligible for inclusion in the Research Sample Repository. Material may be submitted by participating treatment centers, centralized laboratories and Cord Blood Banks. Hematopoietic Cell Transplantation or Other Cellular Therapy Recipients * All U.S. recipients of allogeneic or autologous HC transplants or cellular therapies are eligible to participate in the Research Sample Repository. This includes adults with and without decision making capacity and children. Patients with Marrow Toxic Injury * Any patient who is treated for a marrow toxic injury at a center participating in the NMDP's Radiation Injury Treatment Network (RITN) is eligible to participate in the Research Sample Repository. This includes adults with and without decision-making capacity and children. * Eligible patients may have received support care only, growth factor support, hematopoietic stem cell transplant or other appropriate medical treatment for marrow toxic injury
Where this trial is running
New Brighton, Minnesota
- NMDP Biorepository — New Brighton, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Stephen Spellman — NMDP Be The Match/CIBMTR
- Study coordinator: Ashley Spahn
- Email: RepositoryIRB@NMDP.ORG
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.