Research on improving treatments for childhood leukemia
Official title: Driving Therapeutic Progress of Childhood Leukemia Through Advanced Translational Research With Immediate and Long-term Impact. Precision Medicine for Childhood Leukemia.
Run by Chinese University of Hong Kong · NCT04478006 · Data updated 2026-11-12
This study is testing new ways to treat childhood leukemia by looking at kids' genes to find better medicines and creating new treatments for those with tough cases.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Hong Kong, Hksar) |
| Status | Recruiting |
| Started | July 1, 2020 |
| Main results expected | June 1, 2028 |
| Study ends | June 1, 2028 |
| Registry record updated | February 3, 2026 |
| Trial ID | NCT04478006 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include children diagnosed with acute lymphoblastic leukemia, acute myeloid leukemia, mixed phenotype acute leukemia, juvenile myelomonocytic leukemia, or myelodysplastic syndromes.
✕Probably not a fit
Patients who are unable to understand English or Chinese, or those who refuse participation, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the genomics and drug sensitivity of childhood leukemia to enhance precision medicine approaches. It consists of two main projects: the first focuses on sequencing genetic material from children with various types of leukemia to identify potential targeted therapies, while the second aims to develop novel antibodies for treating high-risk cases using animal models. The goal is to tailor treatments based on individual patient profiles and improve outcomes for those with relapsed or refractory leukemia.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer targeted therapies for children with high-risk leukemia.
How similar studies have gone: Other studies have shown promise in using genomics and targeted therapies for childhood leukemia, indicating that this approach has potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
List of inclusion criteria: 1. acute lymphoblastic leukemia (ALL) or 2. acute myeloid leukemia (AML) or 3 .mixed phenotype acute leukemia (MPAL) or 4\. juvenile myelomonocytic leukemia (JMML) or 5\. myelodysplastic syndromes (MDS) or 6\. normal bone marrow donor List of exclusion criteria: 1. This study will not recruit subjects who are unable to understand English or Chinese. 2. Patient or parent refusal
Where it's running
-
Hong Kong Children Hospital
Hong Kong, Hksar, China Recruiting
Study contacts
- Principal investigator: Kam Tong Leung, Ph. D. — Chinese University of Hong Kong
- Study coordinator: Kathy Chan, Ph. D.
- Email: kathyyychan@cuhk.edu.hk
- Phone: 852-35052858
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.