Clinical trial Recruiting at 1 site Observational Ages Any age to 18

Research on improving treatments for childhood leukemia

Official title: Driving Therapeutic Progress of Childhood Leukemia Through Advanced Translational Research With Immediate and Long-term Impact. Precision Medicine for Childhood Leukemia.

Run by Chinese University of Hong Kong · NCT04478006 · Data updated 2026-11-12

This study is testing new ways to treat childhood leukemia by looking at kids' genes to find better medicines and creating new treatments for those with tough cases.

Quick facts

Study typeObservational
AgesAny age to 18 Years
SexAll
Enrollment300 (estimated)
SponsorChinese University of Hong Kong
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Hong Kong, Hksar)
StatusRecruiting
StartedJuly 1, 2020
Main results expectedJune 1, 2028
Study endsJune 1, 2028
Registry record updatedFebruary 3, 2026
Trial IDNCT04478006 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include children diagnosed with acute lymphoblastic leukemia, acute myeloid leukemia, mixed phenotype acute leukemia, juvenile myelomonocytic leukemia, or myelodysplastic syndromes.

Probably not a fit

Patients who are unable to understand English or Chinese, or those who refuse participation, will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the genomics and drug sensitivity of childhood leukemia to enhance precision medicine approaches. It consists of two main projects: the first focuses on sequencing genetic material from children with various types of leukemia to identify potential targeted therapies, while the second aims to develop novel antibodies for treating high-risk cases using animal models. The goal is to tailor treatments based on individual patient profiles and improve outcomes for those with relapsed or refractory leukemia.

Why it matters

Potential benefit: If successful, this research could lead to more effective and safer targeted therapies for children with high-risk leukemia.

How similar studies have gone: Other studies have shown promise in using genomics and targeted therapies for childhood leukemia, indicating that this approach has potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
List of inclusion criteria:

1. acute lymphoblastic leukemia (ALL) or
2. acute myeloid leukemia (AML) or

3 .mixed phenotype acute leukemia (MPAL) or

4\. juvenile myelomonocytic leukemia (JMML) or

5\. myelodysplastic syndromes (MDS) or

6\. normal bone marrow donor

List of exclusion criteria:

1. This study will not recruit subjects who are unable to understand English or Chinese.
2. Patient or parent refusal

Where it's running

  • Hong Kong Children Hospital
    Hong Kong, Hksar, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.