Research on how maternal lifestyle affects fetal development
Normal Development of the Human Fetus and the Influences and Mechanisms by Which That Development Occurs and is Perturbed
This study looks at how a mother's habits like smoking and drinking during pregnancy can affect her baby's growth and health later in life.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1200 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | University of Aberdeen Academic / other |
| Locations | 1 site (Aberdeen) |
| Trial ID | NCT04613583 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the impact of maternal lifestyle factors, such as smoking, alcohol use, and drug exposure, on fetal development and long-term health outcomes. By analyzing fetal tissues collected from women at 7-20 weeks of gestation, the researchers will explore the mechanisms through which these exposures influence the fetal endocrine system and overall development. The study employs a range of laboratory techniques to assess hormones, proteins, and genetic material in the fetal tissues, collaborating with various research groups to enhance the understanding of fetal programming. The findings could provide insights into preventing adverse health conditions linked to in-utero exposures.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 16 years and older, between 7-20 weeks of gestation, with normal fetal development.
Not a fit: Patients with identified fetal anomalies or significant emotional distress may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing long-term health issues in individuals exposed to harmful substances during pregnancy.
How similar studies have performed: While there have been studies on fetal exposure to harmful substances, this specific approach to directly analyze human fetal tissues is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women at 7-20 weeks of gestation (critical stage of fetal development). * Women aged 16 years and older, deemed capable of making a rational decision. * Absence of fetal anomaly at ultrasound scan (only normal fetuses are required). * Women who are fluent English speakers. This is in order to ensure the woman understands that fetal tissues will be collected. Exclusion Criteria: * Women exhibiting considerable emotional distress. * Fetal anomalies identified at ultrasound scan.
Where this trial is running
Aberdeen
- University of Aberdeen — Aberdeen, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Paul A Fowler, PhD — University of Aberdeen
- Study coordinator: Paul A Fowler, PhD
- Email: p.a.fowler@abdn.ac.uk
- Phone: +44 1224 437528
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.