Research on genetic markers for diabetic ulcers and personalized treatment targets

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research collects blood, ulcer tissue, and fecal samples from patients with diabetic ulcers to analyze genetic markers linked to ulcer risk and healing. The study aims to integrate multi-omics data to create a prediction model for diabetic ulcer risk. By identifying key genetic variations and their regulatory pathways, the research seeks to discover new drug targets that could enhance healing, paving the way for personalized treatment approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\) Subjects who voluntarily participate in this clinical study and sign informed consent;
* 2\) Patients with type 2 diabetes and diabetic ulcers;
* 3\) Disease duration ≥ 10 years or age ≥ 55 years at enrollment;
* 4\) Inpatient or outpatient who can be monitored by the same investigating team throughout the duration of the study.

Exclusion Criteria:

* 1\) Severe vascular occlusion or impairment;
* 2\) Patients with congenital heart disease, aortic dissection, or other severe cardiovascular diseases;
* 3\) Patients with ulcers caused by factors other than diabetes;
* 4\) Patients with severe liver and kidney dysfunction or serious neurological impairment.

Where it's running

• The First Affiliated Hospital of University of South China
  Hengyang, Hunan, China Recruiting

Study contacts

• Study coordinator: Jiecan Zhou, Prof.
• Email: zhoujiecan@fsyy.usc.edu.cn
• Phone: +86-734-8279018

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Miro3D Wound Matrix for Diabetic Foot Ulcers

  This study tests whether adding Miro3D Wound Matrix to standard care helps healing diabetic foot ulcers in adults.

  Recruiting at 6 sites Reprise Biomedical, Inc. · Phoenix, Arizona and 13 other locations · NCT07632001

• Nu-3 Gel at multiple doses for mildly infected diabetic foot ulcers

  A phase 2a study will test whether Nu-3 gel, applied on infected diabetic foot ulcers, can reduce bacteria and help heal at three different dose levels in adults with diabetes.

  Recruiting at 6 sites Phase 2 Lakewood-Amedex Inc · Los Angeles, California and 5 other locations · NCT07565506

• Nitric oxide–generating dressing for diabetic foot ulcers

  This real-world study tests a nitric oxide–generating dressing on adults with diabetic foot ulcers to see how well it works and how safe it is.

  Recruiting ConvaTec Inc. · Ashton-under-Lyne, England · NCT07438951

• Using Miro3D Wound Matrix to Heal Diabetic Foot Ulcers

  This study is testing if adding a special wound dressing called Miro3D to regular care can help people with early-stage diabetic foot ulcers heal faster.

  Recruiting Reprise Biomedical, Inc. · Coconut Creek, Florida and 2 other locations · NCT06939686

• Using Miro3D Wound Matrix to Heal Complex Wounds

  This study is testing if a new wound treatment made from pig liver can help heal tough wounds and reduce pain for adults with chronic ulcers and other serious skin issues.

  Recruiting Reprise Biomedical, Inc. · Coconut Creek, Florida and 1 other locations · NCT06939673

• Comparing Amnion Membrane Allograft and Standard Care for Diabetic Foot Ulcers

  This study is testing whether a new amniotic membrane treatment can help heal diabetic foot ulcers better than a standard collagen dressing.

  Recruiting Skye Biologics Holdings, LLC · Roanoke, Virginia · NCT06767501

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.