Research on genetic factors in Turner Syndrome and heart defects

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the genetic differences between women with Turner Syndrome who have Bicuspid Aortic Valve and those who do not. By analyzing genetic samples and medical histories from participants, the researchers will identify patterns and prevalence of congenital heart defects associated with Turner Syndrome. The study will utilize chromosomal microarrays and exome sequencing to uncover genetic variants linked to cardiovascular complications. The findings could enhance the understanding of heart defect risks in Turner Syndrome patients and improve their clinical management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of Turner Syndrome

Exclusion Criteria:

* Diagnosis excluding Turner Syndrome

Where it's running

• University of Texas Health Science Center Houston
  Houston, Texas, United States Recruiting

Study contacts

• Study coordinator: Siddharth Prakash, MD, PhD
• Email: Siddharth.K.Prakash@uth.tmc.edu
• Phone: 7135007003

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Inpegsomatropin vs Givopegsomatropin for short stature in girls with Turner syndrome

  A 52-week, multicenter, randomized study tests whether Inpegsomatropin injections help prepubertal girls with Turner syndrome grow taller compared with a known treatment.

  Recruiting at 49 sites Phase 3 Xiamen Amoytop Biotech Co., Ltd. · Anyang and 50 other locations · NCT07614152

• Parental plans and pregnancy outcomes in 93 women with Turner syndrome

  This project describes parental plans and pregnancy outcomes for adult women with Turner syndrome treated at Strasbourg University Hospitals between 2009 and 2019.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07344012

• Once-weekly lonapegsomatropin versus daily somatropin for children and adolescents with short stature due to growth-hormone-sufficient conditions

  It will test whether a once-weekly injection of lonapegsomatropin helps children and teens with Turner syndrome, SHOX mutation, small-for-gestational-age, or idiopathic short stature grow as well as or better than daily somatropin.

  Recruiting at 56 sites Phase 3 Ascendis Pharma A/S · Phoenix, Arizona and 55 other locations · NCT07221851

• Bleeding patterns with sequential versus continuous progesterone in adolescents with Turner syndrome

  This study will test whether taking progesterone continuously or in a sequential (monthly) schedule changes bleeding patterns in adolescents with Turner syndrome who are on estrogen replacement therapy.

  Recruiting Phase 4 Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT06834594

• Investigating liver health in adults with Turner Syndrome

  This study looks at liver health in adults with Turner Syndrome to see how common liver problems are and what might cause them.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06794190

• Exercise testing in girls with Turner Syndrome

  This study tests how well girls aged 8-18 with Turner Syndrome can exercise by measuring their heart and lung performance during a special exercise test.

  Recruiting University Hospital, Ghent · Ghent · NCT06780514

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.