Research on genes linked to extreme longevity in specific populations
Official title: Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population
Run by Albert Einstein College of Medicine · NCT00707694 · Data updated 2026-11-12
This study is trying to find out which genes help people aged 95 and older live longer and healthier lives, especially by looking at Ashkenazi Jewish populations.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Albert Einstein College of Medicine Academic / other |
| Locations | 2 sites (New York, New York and 1 other locations) |
| Status | Recruiting |
| Started | July 1998 |
| Main results expected | December 2032 |
| Study ends | December 2032 |
| Registry record updated | January 2, 2026 |
| Trial ID | NCT00707694 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are Ashkenazi Jews aged 95 and older, as well as their offspring.
✕Probably not a fit
Patients who are not of Ashkenazi descent or who do not meet the age criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify specific genes and mutations associated with extreme longevity, particularly in individuals aged 95 and older. The research focuses on understanding how these genetic factors contribute to healthier aging and the prevention of age-related diseases. By studying Ashkenazi Jewish populations, the project seeks to uncover biological functions of longevity-related genes and explore potential therapies that could mimic these genetic advantages in others. The study involves participants living in private homes and a senior living facility in New York.
Why it matters
Potential benefit: If successful, this research could lead to therapies that enhance healthy aging and longevity for individuals lacking the genetic profile for extreme longevity.
How similar studies have gone: While studies on genetics and aging have been conducted, this specific approach focusing on Ashkenazi populations and extreme longevity is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ashkenazi Jewish, age 95+, * Offspring of person age 95+, * Offspring of parents who died age 70 or younger. Exclusion Criteria: * Non-Ashkenazis
Where it's running
-
Private Homes
New York, New York, United States Recruiting -
Hebrew Home Riverdale
Riverdale, New York, United States Recruiting
Study contacts
- Principal investigator: Nir Barzilai, MD — Albert Einstein College of Medicine
- Study coordinator: Tina Gao
- Email: tina.gao@einsteinmed.edu
- Phone: 718-839-7176
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Spatial navigation training using immersive VR in older adults with mild cognitive impairment
This trial tests whether older adults with mild cognitive impairment can complete a 24-session immersive VR navigation training and whether EEG together with VR can show brain activation changes during learning.
-
Morbidity and mortality after serratus anterior plane block for unilateral anterolateral rib fractures
This study tests whether giving a serratus anterior plane block (SAPB) within 24 hours to adults with multiple unilateral anterolateral rib fractures can reduce complications like pneumonia, shorten hospital stay, improve discharge outcomes, and lower death compared with usual opioid-based pain control.
-
Monitoring linezolid blood levels to reduce treatment interruptions in rifampin-resistant TB
This project will test whether checking linezolid blood levels and adjusting doses helps people with rifampin-resistant TB stay on treatment longer.
-
Impact of Reiki on recovery for women having breast surgery
This study is testing if a special relaxation technique called Medical Reiki can help women recovering from breast cancer surgery feel better and improve their quality of life.
-
Lactose-containing versus lactose-free milk for diabetes prevention in people with lactase non-persistence
This trial will test whether drinking lactose-containing milk instead of lactose-free milk for 12 weeks changes gut bacteria and improves blood sugar in people with lactase non-persistence and prediabetes.
-
Digital peer-support program using recovery stories for suicidal adolescents
The team will try a brief, low-cost digital program that shares short recovery stories to see if it reduces suicidal thoughts in ethnically diverse teens in The Bronx.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.