Research on genes linked to extreme longevity in specific populations
Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population
Albert Einstein College of Medicine · NCT00707694
This study is trying to find out which genes help people aged 95 and older live longer and healthier lives, especially by looking at Ashkenazi Jewish populations.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Albert Einstein College of Medicine (other) |
| Locations | 2 sites (New York, New York and 1 other locations) |
| Trial ID | NCT00707694 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify specific genes and mutations associated with extreme longevity, particularly in individuals aged 95 and older. The research focuses on understanding how these genetic factors contribute to healthier aging and the prevention of age-related diseases. By studying Ashkenazi Jewish populations, the project seeks to uncover biological functions of longevity-related genes and explore potential therapies that could mimic these genetic advantages in others. The study involves participants living in private homes and a senior living facility in New York.
Who should consider this trial
Good fit: Ideal candidates for this study are Ashkenazi Jews aged 95 and older, as well as their offspring.
Not a fit: Patients who are not of Ashkenazi descent or who do not meet the age criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to therapies that enhance healthy aging and longevity for individuals lacking the genetic profile for extreme longevity.
How similar studies have performed: While studies on genetics and aging have been conducted, this specific approach focusing on Ashkenazi populations and extreme longevity is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ashkenazi Jewish, age 95+, * Offspring of person age 95+, * Offspring of parents who died age 70 or younger. Exclusion Criteria: * Non-Ashkenazis
Where this trial is running
New York, New York and 1 other locations
- Private Homes — New York, New York, United States (RECRUITING)
- Hebrew Home Riverdale — Riverdale, New York, United States (RECRUITING)
Study contacts
- Principal investigator: Nir Barzilai, MD — Albert Einstein College of Medicine
- Study coordinator: Tina Gao
- Email: tina.gao@einsteinmed.edu
- Phone: 718-839-7176
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Extreme Longevity, 95 years of age and older