Research on bronchiectasis to improve personalized treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on bronchiectasis, a complex and heterogeneous lung disorder. It aims to identify different patient subgroups, known as phenotypes and endotypes, during stable disease and exacerbations. By analyzing clinical data, microbiological profiles, and inflammatory markers from up to 1000 patients, the study seeks to develop strategies for personalized medicine. The findings may help in validating biomarkers and identifying patient populations that could benefit from targeted treatments in future clinical trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A previous CT scan showing bronchiectasis along with compatible clinical syndrome of cough, sputum production and/or recurrent respiratory tract infections.
* A primary diagnosis of bronchiectasis made by a respiratory physician
* At the screening visit the individual will have been clinically stable for 4 weeks indicated by the lack of any treatment with antibiotics or corticosteroids for a pulmonary exacerbation in the previous 4 weeks.

Exclusion Criteria:

* Inability to give informed consent
* \<18years of age
* Patients with active tuberculosis
* Treatment with antibiotics or corticosteroids for a pulmonary exacerbation in the previous 4 weeks
* Bronchiectasis due to cystic fibrosis

Where it's running

• University of Dundee
  Dundee, United Kingdom Recruiting

Study contacts

• Principal investigator: James D Chalmers, MD, PhD — GSK/British Lung Foundation Chair of Respiratory Research
• Study coordinator: James D Chalmers, MD, PhD
• Email: james.chalmers@nhs.scot
• Phone: 01382660111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Azithromycin added to usual care to see if it lowers bronchiectasis flare-ups

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• Wearable sensors and AI to detect chest infection flare-ups in adults with cystic fibrosis or bronchiectasis

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• Home use of the LibAirty airway clearance system for adults with bronchiectasis

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• Autologous Basal Layer Stem Cells to Treat Bronchiectasis

  Researchers will test autologous basal layer stem cells delivered through the airways to see if they can safely improve lung tissue in adults with bronchiectasis.

  Recruiting at 2 sites Phase 1 Ruijin Hospital · Qionghai, Hainan and 1 other locations · NCT06987214

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.