Research on Acute Promyelocytic Leukemia in Asia
Official title: The Acute Promyelocytic Leukaemia Asian Consortium (APL-AC) Project
Run by The University of Hong Kong · NCT04251754 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether taking arsenic trioxide by mouth works as well as getting it through an IV for treating Acute Promyelocytic Leukemia in patients across Asia.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | The University of Hong Kong Academic / other |
| Drugs / interventions | gemtuzumab, chemotherapy |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT04251754 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 or older diagnosed with Acute Promyelocytic Leukemia with the PML/RARA fusion gene.
✕Probably not a fit
Patients with Acute Myeloid Leukemia that do not have the PML/RARA fusion gene or variant RARA translocation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to gather collaborative data on the epidemiology, clinicopathologic features, and treatment outcomes of newly diagnosed and relapsed Acute Promyelocytic Leukemia (APL) in Asia. It will compare the efficacy of oral arsenic trioxide (oral-As2O3) with intravenous arsenic trioxide (i.v.-As2O3) in treating APL, leveraging both retrospective and prospective data from various Asian countries. The study seeks to establish the long-term benefits of oral-As2O3, which has shown promising results in Hong Kong, and to facilitate its broader application across Asia.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for APL, enhancing patient outcomes across Asia.
How similar studies have gone: Other studies have shown success with arsenic trioxide treatments for APL, but this specific approach of oral-As2O3 in a broader Asian context is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Patients aged 18 or above * Acute promyelocytic leukaemia with PML/RARA * Acute myeloid leukaemia with variant RARA translocation Exclusion criteria: -Acute myeloid leukaemia without PML/RARA or variant RARA translocation
Where it's running
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Department of Medicine, the University of Hong Kong, Queen Mary Hospital
Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Harinder Gill, MD — The University of Hong Kong
- Study coordinator: Harinder Singh Harry Gill, MD
- Email: gillhsh@hku.hk
- Phone: +852 22554542
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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QTX-2101 (oral arsenic) plus ATRA for adults with low- or intermediate-risk APL
This Phase 3 trial tests whether an oral arsenic capsule (QTX-2101) combined with ATRA works well and is safe for adults aged 18–70 with newly diagnosed low- or intermediate-risk acute promyelocytic leukemia.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.