Replantation versus splinting for loose lower front teeth
Clinical and Radiographic Evaluation of Intentional Replantation Treatment in Periodontally Hopeless Teeth, Randomized Controlled Clinical Study
This trial will try planned replantation plus splinting versus splinting alone to see which better helps adults with severe periodontitis and very loose lower front teeth.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Saglik Bilimleri Universitesi Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07141680 on ClinicalTrials.gov |
What this trial studies
Fifty adults (18–65) with severe clinical attachment loss and at least 50% alveolar bone loss in lower anterior incisors will be randomized to two groups. All participants receive non-surgical periodontal treatment and conventional root canal therapy before allocation to either splinting alone or planned replantation plus splinting. The replantation procedure uses atraumatic extraction, careful root surface debridement, a brief tetracycline soak, and repositioning into the socket, while the control arm receives only splinting after root canal treatment. Clinical periodontal indices, patient-reported VAS scores, and radiographs will be collected at baseline, 1, 3, and 6 months to compare mobility, healing, symptoms, and radiographic changes.
Who should consider this trial
Good fit: Ideal candidates are non-smoking adults aged 18–65 with Miller grade 3 mobility and severe attachment/bone loss (≥50% of root) in lower anterior incisors who prefer to retain the tooth and have adjacent teeth with acceptable bone levels.
Not a fit: Patients with root fracture, root resorption, ankylosis, uncontrolled systemic disease, or who smoke are unlikely to benefit or may be excluded from the procedure.
Why it matters
Potential benefit: If successful, this approach could help preserve natural lower front teeth, reduce mobility, and improve function and comfort compared with splinting alone.
How similar studies have performed: Intentional replantation has shown mixed but sometimes favorable results in case series and small cohorts, but randomized controlled comparisons against splinting are limited, making this a relatively novel controlled test.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients are systemically healthy or have their systemic conditions under control. * Lower anterior incisors (42, 41, 31, 32) will be included. * Mobility classification will be Miller 3. * Radiograph showing 50% or more bone loss at the root. * Probing depth of 5 mm or more. * Bone level of adjacent teeth at ⅔ or better than the root. * Mobility of adjacent teeth will be Miller 0 or Miller 1. * The patient prefers to keep the tooth in the mouth rather than having it extracted. Exclusion Criteria: * Systemic Comorbidity * Smoking * Root Resorption * Root Fracture or Crack * Ankylosis of the Tooth
Where this trial is running
Istanbul
- University of Health Sciences, Hamidiye Faculty of Dentistry. — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Tuğçe PAKSOY associate professor
- Email: tugce.paksoy@sbu.edu.tr
- Phone: +90 553 449 04 52
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.