Renal Involvement in Wilson's Disease
Official title: Description of Renal Involvement in Wilson's Disease
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT07075393 · Data updated 2026-11-12
This study tests how Wilson's disease affects the kidneys and who might be at risk for kidney problems.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 7 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | July 22, 2026 |
| Main results expected | July 2029 |
| Study ends | July 2029 |
| Registry record updated | October 1, 2026 |
| Trial ID | NCT07075393 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 7 or older with a confirmed Wilson's disease diagnosis and Leipzig score ≥ 4 who have not undergone organ transplantation and do not have other non-Wilson-related kidney diseases.
✕Probably not a fit
Patients with Wilson’s disease who do not have kidney involvement or who have other primary kidney diseases unrelated to Wilson’s may not experience direct kidney-related benefits from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to describe renal involvement in patients with Wilson's disease by conducting comprehensive kidney evaluations. It will examine indirect kidney complications such as hepatorenal and cardiorenal syndromes, as well as signs of direct copper-related kidney damage, including tubular dysfunction. The study will enroll participants aged 7 and older with a Leipzig score of 4 or higher and collect full renal workups to characterize kidney function and electrolyte/metabolic disturbances. Results could improve understanding of kidney risks in Wilson’s disease and guide screening or management strategies.
Why it matters
Potential benefit: Findings may help identify kidney-related complications earlier and inform monitoring strategies for people with Wilson's disease.
How similar studies have gone: Previous literature suggests copper can affect renal tubules, but systematic, comprehensive renal characterization in Wilson’s disease remains limited, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged 7 years and older * Diagnosed with Wilson's disease, with a Leipzig score ≥ 4 Exclusion Criteria: * Patient who has undergone organ transplantation * Known renal comorbidity unrelated to Wilson's disease * Pregnant or breastfeeding woman
Where it's running
-
Hôpital Fondation Adolphe de Rothschild
Paris, France Recruiting
Study contacts
- Study coordinator: Amelie Yavchitz, Dr
- Email: ayavchitz@for.paris
- Phone: +33148036454
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study tests PM577a, a gene-editing treatment, to see if it is safe and may help people with Wilson disease who have a p.H1069Q ATP7B mutation.
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This study is testing a new gene therapy called LY-M003 to see if it is safe and effective for people with Wilson Disease.
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This study is creating a detailed registry to collect information on rare diseases like amyloidosis and sarcoidosis to help improve how they are diagnosed and treated.
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This study is collecting information about Wilson Disease in Spain to help understand how common it is and improve how it's diagnosed and treated.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.