Remote ischemic preconditioning and mindfulness for people with mild hypertension

Long-term of Remote Ischemic Preconditioning and Mindfulness in Patients With Mild Hypertension

This project will test whether adding regular remote ischemic preconditioning and mindfulness to lifestyle changes can lower blood pressure in adults with mild hypertension (SBP 140–159 mmHg or DBP 90–99 mmHg).

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 400 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Henan Institute of Cardiovascular Epidemiology (other)
• Locations: 1 site (Zhengzhou, Henan)
• Trial ID: NCT04753840 on ClinicalTrials.gov

What this trial studies

This is an open-label, parallel-group trial enrolling 200 patients with mild hypertension at a single center in Zhengzhou, Henan. Participants receive lifestyle interventions and are assigned to groups that include remote ischemic preconditioning, mindfulness training, sham procedures, or standard antihypertensive drug therapy in predefined combinations. The main outcome is change in 24-hour ambulatory blood pressure measured at baseline and after 3 months, with additional measures of heart rate, pulse pressure, daytime/nighttime blood pressure components, and a panel of neurohormonal and vascular biomarkers. The study compares physiological and biomarker changes between the groups to see if non-drug approaches provide clinically meaningful blood pressure reduction.

Who should consider this trial

Good fit: Adults diagnosed with mild primary hypertension (systolic 140–159 mmHg or diastolic 90–99 mmHg) who can tolerate remote ischemic preconditioning and attend visits at the Zhengzhou site are ideal candidates.

Not a fit: People with secondary (non-essential) hypertension, uncontrolled severe arrhythmia, diabetes with instability, significant electrolyte disturbances, severe cardiac or renal disease, or who cannot tolerate RIPC are unlikely to benefit or be eligible.

Why it matters

Potential benefit: If successful, this could offer a non-drug option to lower blood pressure for people with mild hypertension.

How similar studies have performed: Small prior studies and pilot data have reported short-term blood pressure reductions with remote ischemic conditioning and with mindfulness approaches, but long-term effects and head-to-head comparisons remain limited.

Eligibility criteria

Inclusion Criteria:

* Diagnosed patients with mild hypertension (SBP: 140\~159mmHg; DBP: 90\~99mmHg)

Exclusion Criteria:

* Cannot tolerate RIPC
* Non-essential hypertension
* patients who have uncontrolled severe arrhythmia, diabetes, electrolyte disturbance
* patients who have severe organic diseases such acute myocardial infarction, cardiac insufficiency, abnormal renal function, etc.

Where this trial is running

Zhengzhou, Henan

• Fuwai central China Cardiovascular hospital — Zhengzhou, Henan, China (RECRUITING)

Study contacts

• Study coordinator: En Li

Conditions: Hypertension