Rehabilitation program for stroke patients to improve motor skills
Training the Surviving Neural Network to Create New Synaptic Connections That Can Maximize Restoration of Motor Functions After Stroke
This study tests a rehabilitation program for stroke patients to see if it can help improve their motor skills by using advanced brain imaging techniques to understand their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Norwegian University of Science and Technology Academic / other |
| Locations | 3 sites (Oslo and 2 other locations) |
| Trial ID | NCT05086055 on ClinicalTrials.gov |
What this trial studies
This study investigates stroke patients using advanced multimodal imaging techniques, including MRI and EEG, to assess brain lesions and functional neural networks. It aims to quantify brain damage, analyze inflammation related to stroke, and monitor improvements in motor skills during rehabilitation. The study will also explore how to train surviving neural networks to form new connections, enhancing motor function recovery. Advanced mathematical models will be developed to predict the effectiveness of rehabilitation strategies.
Who should consider this trial
Good fit: Ideal candidates are patients with subcortical strokes resulting in arm motor deficits who are admitted to the stroke unit at St Olav's Hospital.
Not a fit: Patients with previous strokes, neurodegenerative diseases, brain tumors, or cognitive dysfunction may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation strategies that significantly enhance motor function recovery in stroke patients.
How similar studies have performed: Other studies utilizing multimodal imaging and rehabilitation techniques have shown promise, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * subcortical strokes resulting in arm motor deficits. * admitted to the stroke unit, St Olav´s Hospital during 2021-2023 Exclusion Criteria: * Previous stroke * neurodegenerative disease * brain tumors * previous neurotrauma or brain operation * aphasia * cognitive dysfunction and claustrophobia preventing MRI examinations.
Where this trial is running
Oslo and 2 other locations
- OsloMet — Oslo, Norway (Recruiting)
- NextMove, NTNU — Trondheim, Norway (Recruiting)
- St Olavs Hospital Stroke Unit — Trondheim, Norway (Recruiting)
Study contacts
- Principal investigator: Axel Sandvig, PhD prof — Norwegian University of Science and Technology
- Study coordinator: Axel Sandvig, PhD ass prof
- Email: axel.sandvig@ntnu.no
- Phone: +46 72575620
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.