Registry to study biomarkers in acute heart failure progression
A Registry Study of Biomarkers in Progression of Acute Heart Failure
Beijing Institute of Heart, Lung and Blood Vessel Diseases · NCT04108182
This study is trying to see if certain blood markers can help doctors understand how acute heart failure gets worse in adults with symptoms like shortness of breath and swelling.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 850 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Beijing Institute of Heart, Lung and Blood Vessel Diseases (other) |
| Locations | 1 site (Beijing) |
| Trial ID | NCT04108182 on ClinicalTrials.gov |
What this trial studies
This observational registry study aims to evaluate the prognostic value of biomarkers in patients experiencing acute heart failure. It will involve collecting data from patients aged 18 and older who present with symptoms such as dyspnea and peripheral edema, alongside specific echocardiographic findings. The study will analyze plasma concentrations of BNP to assess their correlation with heart failure progression. By understanding these biomarkers, the study seeks to improve patient management and outcomes in acute heart failure.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with acute exacerbation of chronic heart failure or new heart failure and specific symptoms and echocardiographic findings.
Not a fit: Patients with a history of cancer, recent surgery, or those experiencing severe complications like cardiogenic shock or sepsis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prognostic tools for managing acute heart failure, ultimately improving patient outcomes.
How similar studies have performed: Other studies have shown promise in using biomarkers for heart failure prognosis, indicating that this approach is supported by previous research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1. Patients aged greater than or equal to 18 years with acute exacerbation of chronic heart failure or new heart failure * 2. With typical symptoms of acute heart failure as follows: Dyspnea, ankle swelling and fatigue (Limited activity endurance), increased jugular pressure, rales and peripheral edema ; * 3. Plasma concentrations of BNP: BNP\>100pg/ML * 4. Echocardiography: Related structural heart disease (left ventricular hypertrophy and/or left atrial enlargement) and/or diastolic dysfunction Exclusion Criteria: * 1. Previous history of cancer or renal replacement therapy * 2.Surgery was performed within a month * 3.Accompanied by cardiogenic shock, sepsis, pneumonia * 4.Eligible patients without informed consent form
Where this trial is running
Beijing
- Beijing Anzhen Hospital — Beijing, China (RECRUITING)
Study contacts
- Study coordinator: Yulin Li, PHD
- Email: lyllyl_1111@163.com
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiovascular Diseases, heart failure