Registry study on factors predicting outcomes in aneurysmal subarachnoid hemorrhage
Official title: Multi-Center Registry Cohort Study on Prognostic Factors and Prediction Model Construction in Aneurysmal Subarachnoid Hemorrhage
Run by Second Affiliated Hospital of Nanchang University · NCT05738083 · Data updated 2026-11-12
This study is trying to find out what factors can help predict how well people with aneurysmal subarachnoid hemorrhage will do after their condition and improve how they are treated.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | Second Affiliated Hospital of Nanchang University Academic / other |
| Locations | 1 site (Nanchang, Jiangxi) |
| Status | Recruiting |
| Started | October 1, 2018 |
| Main results expected | December 30, 2028 |
| Study ends | December 30, 2029 |
| Registry record updated | April 30, 2026 |
| Trial ID | NCT05738083 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with subarachnoid hemorrhage due to a ruptured intracranial aneurysm who meet specific clinical criteria.
✕Probably not a fit
Patients with aneurysm rupture bleeding for more than 24 hours before hospital admission or those with incomplete imaging or blood test data may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
PROSAH-MPC is a collaborative research project involving multiple neurosurgical centers in China that aims to identify prognostic factors and develop prediction models for complications, disability, and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). The study utilizes a large, multi-center, prospective cohort design to gather extensive clinical and radiological data, including demographics, medical histories, and imaging features. By employing machine learning techniques, the study seeks to extract critical predictive features from imaging data, enhancing the accuracy of the developed models. This comprehensive approach aims to provide a better understanding of aSAH outcomes and improve patient management.
Why it matters
Potential benefit: If successful, this study could lead to improved prediction of complications and outcomes for patients with aneurysmal subarachnoid hemorrhage.
How similar studies have gone: Other studies have shown success in using multi-center approaches and machine learning for predicting outcomes in similar conditions, indicating a promising avenue for this research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subarachnoid hemorrhage confirmed by computed tomography (CT); * Cerebral angiography (CTA) and digital subtraction angiography (DSA) examination confirming intracranial aneurysm rupture as the cause of the subarachnoid hemorrhage; * Blood routine, biochemical function, blood coagulation function, and craniocerebral CT performed within 24 hours of symptom onset; * Underwent aneurysm clipping by surgery or endovascular embolization within 72 hours after-onset. Exclusion Criteria: * Aneurysm rupture bleeding time exceeding 24 hours before hospital admission; * Incomplete image data or blood test information; * Long-term use of anticoagulant medications such as aspirin or warfarin; * Admitted to hospital with active infectious diseases; * long-term anticoagulant drugs such as aspirin, wave dimensions; * Presence of other intracranial vascular malformations.
Where it's running
-
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China Recruiting
Study contacts
- Principal investigator: Qianxue Chen, Prof — Renmin Hospital of Wuhan University
- Study coordinator: Xingen Zhu, Prof
- Email: zxg2008vip@163.com
- Phone: 13803546020
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Nitric Oxide Use to Predict Vasospasm in Aneurysmal Subarachnoid Hemorrhage
This study tests whether nitric oxide consumption in CSF can predict cerebral vasospasm in patients with aneurysmal SAH.
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Multi-omics program to understand complications and outcomes after aneurysmal subarachnoid hemorrhage
This project will test if combining blood, cerebrospinal fluid, urine, imaging, and multi-omics data can find biomarkers that predict complications and outcomes in adults with aneurysmal subarachnoid hemorrhage.
-
Dome-only coiling for severe aneurysmal subarachnoid hemorrhage
This will test a minimally invasive dome-protection coiling procedure to prevent re-bleeding in adults who have had a severe aneurysmal subarachnoid hemorrhage.
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Cilostazol to help prevent delayed brain ischemia after aneurysm bleed
This study tests whether cilostazol can reduce delayed brain ischemia and improve outcomes after aneurysmal subarachnoid hemorrhage in adults who had recent aneurysm treatment.
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Transcutaneous Vagal Nerve Stimulation to help with brain vessel narrowing after aneurysm rupture
This trial tests whether using a noninvasive nerve stimulation device can reduce cerebral vasospasm after an aneurysmal brain bleed in adults 18–65 who are undergoing standard treatment.
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Tocilizumab-aazg to reduce stroke risk after a ruptured brain aneurysm
This trial will try to see if a single IV dose of tocilizumab-aazg is safe and can help prevent delayed strokes in adults who have had a ruptured brain aneurysm (aneurysmal subarachnoid hemorrhage).
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.