Registry for treating vertebral artery stenosis to prevent stroke
Official title: Vertebral Artery Origin Treatment Via Endovascular Techniques Registry (VOTER)
Run by St. Louis University · NCT03999983 · Data updated 2026-11-12
This study collects information from patients who have had strokes caused by narrowed vertebral arteries to see if treatments like stenting and medication can help prevent more strokes over 18 months.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | St. Louis University Academic / other |
| Locations | 10 sites (Jacksonville, Florida and 9 other locations) |
| Status | Recruiting |
| Started | November 19, 2019 |
| Main results expected | March 2026 |
| Study ends | December 2026 |
| Registry record updated | February 12, 2025 |
| Trial ID | NCT03999983 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 90 who have had a posterior circulation ischemic event and confirmed significant stenosis in the vertebral artery.
✕Probably not a fit
Patients who are pregnant, have contraindications to anti-platelet drugs, or have severe comorbidities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study is a registry that collects data on patients who have experienced strokes due to vertebral artery origin stenosis (VAOS). It includes both retrospective and prospective data on patients treated with stenting and medical management. The aim is to evaluate clinical outcomes over an 18-month period following treatment. The registry focuses on understanding the effectiveness of these interventions in preventing recurrent strokes.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into effective treatments for preventing recurrent strokes in patients with vertebral artery stenosis.
How similar studies have gone: Other studies have explored similar interventions for vertebral artery stenosis, but the specific registry approach may provide novel insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients between 18 and 90 years of age 2. Patient has experienced a posterior circulation ischemic event 3. Patient has angiographically confirmed bilateral vertebral artery origin disease (Hypoplasia, occlusion, or stenosis). 4. Patient has \>50% stenosis on the side being targeted for therapy Exclusion Criteria: 1. Pregnant women 2. Contrast Indication to the use of anti-platelet drugs 3. There is tandem vertebral or basilar artery stenosis 4. The serum creatinin is \>2.5 5. Baseline modified Rankin score is \>3 6. \< 5 years life expectancy
Where it's running
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Baptist Medical Center Jacksonville
Jacksonville, Florida, United States Recruiting -
University of Southern Florida
Tampa, Florida, United States Recruiting -
Northwestern Medicine Regional Medical Group
Winfield, Illinois, United States Recruiting -
University of Iowa
Iowa City, Iowa, United States Recruiting -
SSM DePaul Hospital
Bridgeton, Missouri, United States Recruiting -
Saint Louis University
St Louis, Missouri, United States Recruiting
Show 4 more locations
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Mercy Health Neuroscience Institute
Toledo, Ohio, United States Recruiting -
Semmes Murphey Clinic
Memphis, Tennessee, United States Recruiting -
Cleveland Clinic
Cleveland, Ohio, United States Not yet recruiting -
Texas Tech University Health Science Center of El Paso
El Paso, Texas, United States Not yet recruiting
Study contacts
- Principal investigator: Randall Edgell, MD — St. Louis University
- Study coordinator: Randall Edgell, MD
- Email: randall.edgell@health.slu.edu
- Phone: 314-977-3129
Similar studies
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Comparing drug-eluting stenting to medical treatment for vertebral artery stenosis
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-
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.