Registry for the Omnipod 5 System in Type 1 Diabetes Patients

Post Market Registry to Collect Real-World Safety and Effectiveness Data for the Omnipod 5 System in Children and Adults With Type 1 Diabetes

Insulet Corporation · NCT06144554

This study is testing how safe and effective the Omnipod 5 insulin delivery system is for both kids and adults with Type 1 Diabetes over a year.

Quick facts

Study typeObservational
Enrollment2200 (estimated)
Ages2 Years and up
SexAll
SponsorInsulet Corporation (industry)
Locations1 site (Buffalo, New York)
Trial IDNCT06144554 on ClinicalTrials.gov

What this trial studies

This observational registry aims to gather real-world evidence on the safety and effectiveness of the Omnipod 5 insulin delivery system in both children and adults with Type 1 Diabetes. A minimum of 2,200 participants will be recruited, including various age groups and insulin-naïve users, to ensure comprehensive data collection over a 12-month follow-up period. Participants will be required to complete assessments and submit A1C samples at specified intervals throughout the study.

Who should consider this trial

Good fit: Ideal candidates include individuals with self-reported Type 1 Diabetes who have recently started or plan to start using the Omnipod 5 system.

Not a fit: Patients who are not using the Omnipod 5 system or those who are currently pregnant may not benefit from this registry.

Why it matters

Potential benefit: If successful, this registry could provide valuable insights into the real-world effectiveness of the Omnipod 5 system, potentially improving diabetes management for patients.

How similar studies have performed: Previous studies on similar insulin delivery systems have shown promising results, indicating that this approach is supported by existing evidence.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Self-reported type 1 diabetes
2. Prescribed, obtained, and have been using the Omnipod 5 System for no more than two weeks or plan to start using the system within the next two weeks
3. Willing to use only the following types of U-100 insulin during the study: Humalog U-100, Novolog, or Admelog
4. Able to read and speak English or Spanish (when available) fluently and reside full time in the United States
5. Willing to collect A1C samples using a provided home kit and send the samples to the registry specific core laboratory at baseline and 3, 6, 9 and 12 months
6. Willing and able to complete registry assessments every two weeks
7. Willing and able to complete registry outcome questionnaires at baseline, 6 months and end of study (or at withdrawal)
8. Is not currently pregnant or planning to become pregnant in the next 12 months and is using a reliable form of birth control
9. Access to internet via phone, tablet and/or computer to use the registry online platform
10. Willing to provide CGM and insulin delivery data collected prior to using the Omnipod 5 System, if available (participants will not be excluded if data is not provided)
11. Willing and able to provide informed consent (or assent) and/or has a parent/guardian willing and able to provide informed consent as applicable

Exclusion Criteria:

1. Diagnosed with sickle cell anemia and/or hemoglobinopathy
2. Planned blood transfusions over the course of the study or has received a blood transfusion within 3 months prior to starting on Omnipod 5
3. Adults that are unable to provide informed consent

Where this trial is running

Buffalo, New York

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Type 1 Diabetes, Omnipod, Automated Insulin Delivery, Registry

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.