Registry for patients with Triple Negative Breast Cancer and hereditary mutations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This registry collects cancer-related information from patients diagnosed with Triple Negative Breast Cancer (TNBC) and those with hereditary genetic mutations linked to breast and ovarian cancer. The goal is to better understand the relationship between genetic changes and cancer outcomes in these patients. Participants can include individuals with TNBC or germline mutations, regardless of their cancer history or genetic testing status. The study aims to gather data that could inform future treatment and management strategies for these conditions.

Why it matters

Who can join: the full rules

Inclusion criteria include:

Triple Negative Breast Cancer

* ER/PR \<10% and HER negative per current ASCO/CAP guidelines
* Stages I-IV
* Any age at diagnosis
* Patient must be within 5 years of diagnosis
* Eligible regardless of genetic testing status
* Genetic testing recommended for patients meeting NCCN and Medicare guidelines

AND/OR

Germline mutation Carriers

* Patients with deleterious or uncertain mutations in HBOC genes (BRCA, PTEN, P53, -PALB2 etc) are eligible regardless of type/site of cancer
* Healthy patients harboring mutations also eligible
* There is no time limit from the time of diagnosis of cancer and enrollment.
* Eligible regardless of personal history of cancer

Exclusion Criteria include:

Triple Negative Breast Cancer -Patient is not within five years of diagnosis

Germline mutation Carriers:

-Patient only carries a HBOC mutation that is classified as "polymorphism" of "favor polymorphism"

Where it's running

• Hays Medical Center Dreiling-Schmidt Cancer Institute
  Hays, Kansas, United States Recruiting
• KCCC West
  Kansas City, Kansas, United States Recruiting
• KCCC Overland Park
  Overland Park, Kansas, United States Recruiting
• Overland Park Regional Medical Center
  Overland Park, Kansas, United States Recruiting
• Salina Regional Health Center - Tammy Walker Cancer Center
  Salina, Kansas, United States Recruiting
• The University of Kansas Cancer Center
  Westwood, Kansas, United States Recruiting

Study contacts

• Principal investigator: Priyanka Sharma, MD — University of Kansas Medical Center
• Study coordinator: Joshua Staley
• Email: jstaley2@kumc.edu
• Phone: 913-588-8548

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.