Registry for patients with microvascular angina
Official title: A Multicenter Registry on the Diagnosis of Patients With Chronic Angina and no Angiographic Coronary Artery Stenosis
Run by Johannes Gutenberg University Mainz · NCT04612322 · Data updated 2026-11-12
This study is trying to learn more about patients with microvascular angina by tracking their heart health and quality of life over five years to see how it affects their overall well-being.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Johannes Gutenberg University Mainz Academic / other |
| Locations | 1 site (Mainz, RLP) |
| Status | Recruiting |
| Started | October 10, 2020 |
| Main results expected | October 10, 2024 |
| Study ends | October 10, 2029 |
| Registry record updated | March 31, 2022 |
| Trial ID | NCT04612322 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 to 85 with chronic coronary syndrome and CCS class II-IV angina who show evidence of reversible ischemia.
✕Probably not a fit
Patients with severe left ventricular dysfunction, recent coronary artery bypass surgery, or significant renal failure may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational registry study aims to better characterize patients with microvascular angina, a condition that significantly impacts prognosis but is poorly defined. It will enroll patients experiencing angina classified as CCS II-IV who are undergoing assessment of microvascular function. Over a duration of up to 5 years, participants will be evaluated at hospital discharge, and through follow-up contacts at 12 months and 5 years. The study will collect data on various cardiovascular outcomes and quality of life measures to identify predictors of prognosis.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of microvascular angina, enhancing patient outcomes.
How similar studies have gone: While there is limited data on similar registry studies specifically for microvascular angina, the approach of characterizing patient phenotypes and outcomes has shown promise in other cardiovascular conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 and \<85 years. * Chronic coronary syndrome (including patients with anginal equivalents) * Angina CCS class II-IV * Evidence of reversible ischemia on non-invasive testing * Availability of the following measurements: 1. Index of microvascular resistances (IMR), 2. Resting full-cycle ratio (RFR), 3. Fractional flow reserve (FFR), 4. Coronary flow reserve (CFR) * Willingness to participate and ability to understand read and signed the informed consent document before the procedure Exclusion Criteria: At least one of the following: * Pregnancy and or lactation. * Medical or psychological conditions that would jeopardize an adequate and orderly participation. * Left ventricular ejection fraction lower than 30% * Previous coronary artery bypass surgery (CABG) to all major branches in the LAD and left circumflex (LCX) territory, such that IMR cannot be measured * Decompensated congestive heart failure (CHF) * Chronic or acute renal failure with creatinine \>2mg/dl * Severe valvular heart disease * Patients with comorbidities limiting life expectancy to less than one year
Where it's running
-
Universitätsmedizin Mainz
Mainz, Rlp, Germany Recruiting
Study contacts
- Study coordinator: Tommaso Gori, Dott med, PhD
- Email: tommaso.gori@unimedizin-mainz.de
- Phone: +496131 17
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Stroke care during COVID-19 waves: patterns in admissions and treatments
This study tests how stroke and TIA care patterns changed during the later waves of the COVID-19 pandemic by analyzing hospital data on admissions, stays, thrombolysis, and thrombectomy.
-
Hydrus stent long-term follow-up after eight years
This follow-up will see if the Hydrus microstent continues to lower eye pressure and remains safe in people with glaucoma who had the implant at least eight years ago.
-
Heart rate variability training to improve glucose metabolism in prediabetes
This study is testing if breathing exercises that help regulate heart rate can improve blood sugar levels in people with prediabetes.
-
Shorter anticoagulation after hip surgery to prevent blood clots
This study is testing if a shorter 10-day treatment with a blood thinner after hip surgery can prevent blood clots just as well as the usual 35-day treatment for patients recovering from the surgery.
-
Comparing in-person and virtual reality exposure for agoraphobia
This trial will try in-person exposure versus virtual reality exposure to see which helps people with agoraphobia (with or without panic) reduce avoidance and anxiety.
-
Registry collecting data on microvascular dysfunction and coronary spasm
This study is collecting information from patients with microvascular dysfunction and coronary spasm to better understand their experiences and improve their care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.