Registry for patients at high risk for pancreatic cancer
Official title: A Prospective Registry for Patients at High-Risk for Pancreatic Cancer
Run by Mayo Clinic · NCT06151223 · Data updated 2026-11-12
This study is creating a registry for people at high risk of pancreatic cancer to see if new tests can help catch the disease early.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | July 13, 2021 |
| Main results expected | July 31, 2031 |
| Study ends | July 31, 2031 |
| Registry record updated | March 10, 2026 |
| Trial ID | NCT06151223 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 18 and older who meet the criteria for being high-risk for pancreatic cancer.
✕Probably not a fit
Patients with a personal history of pancreatic ductal adenocarcinoma or those who have undergone total pancreatectomy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to create a registry for individuals at high risk of developing pancreatic ductal adenocarcinoma (PDAC). It focuses on the discovery and validation of early detection tests and employs advanced machine learning algorithms to analyze databases and images for identifying early stages of pancreatic cancer. The study will also facilitate the development of interventional protocols aimed at early detection of PDAC. Participants will undergo bio-specimen collection and MRI to support these objectives.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection of pancreatic cancer, improving treatment outcomes for high-risk patients.
How similar studies have gone: Other studies have shown promise in using machine learning for early detection of cancers, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 year * Able to provide written informed consent * Meets criteria as a High-Risk Individual as defined by protocol Exclusion Criteria: * Individual who has a personal history of pancreatic ductal adenocarcinoma (PDAC) * History of total pancreatectomy
Where it's running
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Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Shounak Majumder, M.D. — Mayo Clinic in Rochester
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Atebimetinib plus gemcitabine and nab‑paclitaxel as first‑line treatment for metastatic pancreatic cancer
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Screening for pancreatic cancer in high-risk individuals
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This study tests whether two investigational RAS inhibitors together can improve outcomes compared with standard chemotherapy in adults with newly diagnosed metastatic pancreatic cancer carrying the KRAS G12D mutation.
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Zoldonrasib + chemotherapy vs placebo + chemotherapy as first-line treatment for metastatic KRAS G12D pancreatic cancer
This trial tests whether adding zoldonrasib to standard chemotherapy helps people with newly diagnosed metastatic KRAS G12D pancreatic cancer.
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Daraxonrasib alone or with gemcitabine and nab-paclitaxel for first-line metastatic pancreatic cancer
This trial will see if daraxonrasib, alone or with gemcitabine and nab-paclitaxel, helps people with newly diagnosed metastatic pancreatic cancer live longer or slow tumor growth compared with standard gemcitabine and nab-paclitaxel.
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Daraxonrasib after surgery for resected pancreatic ductal adenocarcinoma (PDAC)
This trial tests whether taking daraxonrasib after surgery can help prevent cancer from coming back in adults with resected PDAC who completed perioperative chemotherapy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.