Registry for Online Adaptive Radiotherapy in Pelvic and Thoracic Tumors
Pelvic and Thoracic Cancer Treated With Online Adapted Radiotherapy: A Prospective Registry-based Phase-II Trial
This study is testing if a new type of radiotherapy that adapts to patients' changing needs can reduce side effects and improve outcomes for people with pelvic or thoracic tumors compared to standard treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 846 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Medical Center Goettingen Academic / other |
| Locations | 1 site (Göttingen) |
| Trial ID | NCT06185062 on ClinicalTrials.gov |
What this trial studies
This observational registry-based trial aims to include patients with pelvic or thoracic tumors who require radiotherapy. It will compare the effectiveness of online Adaptive Radiotherapy (oART) against Image Guided Radiotherapy (IGRT) in reducing acute radiotherapy-related toxicity and improving clinical outcomes. The study will assess both clinical endpoints, such as tumor control and quality of life, and technical endpoints related to treatment precision. By utilizing daily imaging and artificial intelligence, the trial seeks to adapt treatment plans to the patient's current anatomy, potentially minimizing side effects.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with pelvic or thoracic tumors that require radiotherapy.
Not a fit: Patients who have previously received radiotherapy at the affected site will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the rate of acute toxicity associated with radiotherapy for patients with pelvic and thoracic tumors.
How similar studies have performed: While online Adaptive Radiotherapy is already in clinical use, this specific comparative analysis against IGRT is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
INCLUSION CRITERIA * Patients with pelvic or thoracic tumors with an indication for radiotherapy * Patient information and declaration of consent * Patients age ≥ 18 years EXCLUSION CRITERIA * Prior radiotherapy in affected site
Where this trial is running
Göttingen
- University Medical Center, Departement of Radiation Oncology — Göttingen, Germany (Recruiting)
Study contacts
- Study coordinator: Laura Anna Fischer
- Email: laura-anna.fischer@med.uni-goettingen.de
- Phone: +49 551 3964501
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.