Registry for knee osteoarthritis pain management outcomes
Official title: Innovations in Genicular Outcomes Registry
Run by Pacira Pharmaceuticals, Inc · NCT05495334 · Data updated 2026-11-12
This study is trying to see how well different pain management treatments work for people with knee osteoarthritis and those who have had knee surgery.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 10000 (estimated) |
| Sponsor | Pacira Pharmaceuticals, Inc Industry-sponsored |
| Locations | 19 sites (Phoenix, Arizona and 18 other locations) |
| Status | Recruiting |
| Started | September 23, 2021 |
| Main results expected | June 30, 2032 |
| Study ends | December 30, 2033 |
| Registry record updated | July 23, 2026 |
| Trial ID | NCT05495334 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients planning to receive treatment for knee osteoarthritis pain within 60 days of screening.
✕Probably not a fit
Patients actively enrolled in other investigational trials or planning surgeries on knees other than the target knee may not benefit from this registry.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This registry captures prospective data on patients receiving various pain management therapies for chronic pain due to knee osteoarthritis or those undergoing knee arthroplasty. Treatments may include cryo nerve block, radiofrequency ablation, intra-articular corticosteroids, viscosupplementation, and opioids. The goal is to optimize pain management and assess outcomes related to these interventions. Patients will complete questionnaires via a registry application to provide valuable data on their experiences and treatment effectiveness.
Why it matters
Potential benefit: If successful, this registry could enhance understanding of effective pain management strategies for knee osteoarthritis, leading to improved patient outcomes.
How similar studies have gone: Other studies have shown success in capturing patient outcomes through registries, indicating that this approach is promising.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Planned to receive treatment for knee OA pain including, but not limited to, knee injections, nerve blocking procedures, or knee arthroplasty within 60 days of screening 2. Able to understand the informed consent and assessment questionnaires and have the ability to complete them in the opinion of the investigator 3. Have access to a smartphone or internet access with a computer/tablet to complete the questionnaires using the registry application Exclusion Criteria: 1. Actively enrolled in an investigational trial that would preclude patients from receiving the site's standard of care for knee OA pain or knee arthroplasty recovery protocol 2. Planning to have a surgery other than on the target knee
Where it's running
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The MORE Foundation
Phoenix, Arizona, United States Recruiting -
Orthopedic Education and Research Institute of So Ca (Hoag)
Irvine, California, United States Recruiting -
Cedars-Sinai Medical Center
Los Angeles, California, United States Recruiting -
Florida Orthopaedic Associates
DeLand, Florida, United States Recruiting -
MidState Orthopedics and Sports Medicine
Alexandria, Louisiana, United States Recruiting -
Louisiana State University /Ochsner
New Orleans, Louisiana, United States Recruiting
Show 13 more locations
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Sinai Hospital of Baltimore
Baltimore, Maryland, United States Recruiting -
Orthopaedic Surgical Associates
North Chelmsford, Massachusetts, United States Recruiting -
OrthoNebraska Clinics
Omaha, Nebraska, United States Recruiting -
Northwell Health
Garden City, New York, United States Recruiting -
Oklahoma Surgical Hospital
Tulsa, Oklahoma, United States Recruiting -
Penn Highlands DuBois
DuBois, Pennsylvania, United States Recruiting -
University Orthopedics Center
State College, Pennsylvania, United States Recruiting -
Campbell Clinic
Germantown, Tennessee, United States Recruiting -
University of Utah
Salt Lake City, Utah, United States Recruiting -
Henry M Jackson Foundation for the Advancement of Military Medicine/Walter Reed National Military Medical Center
Bethesda, Maryland, United States Terminated -
Jersey City Medical Center
Jersey City, New Jersey, United States Terminated -
Genesee Orthopedics and Plastic Surgery (St. Elizabeth Med Center/ Apex Surgical Center)
New Hartford, New York, United States Completed -
Blue Nine Systems
Asheville, North Carolina, United States Terminated
Study contacts
- Study coordinator: Kate Fasel, BSN
- Email: IGOR@pacira.com
- Phone: 1-520-490-5355
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Effects of virtual reality on walking in adults with knee osteoarthritis
This study tests how immersive virtual reality environments—designed to feel safe or to provoke fear—affect walking and worry about movement in adults 50 and older with knee osteoarthritis and in healthy peers.
-
Weekly berobenatide for knee osteoarthritis in adults who are overweight or obese
This study tests whether weekly berobenatide helps reduce knee pain and improve function, while also affecting body weight, in adults with knee osteoarthritis who are overweight or obese (with or without type 2 diabetes).
-
Autologous adipose-derived stem cell injections for knee osteoarthritis
We’re testing whether injecting a patient’s own fat-derived stem cells into the knee can help people with knee OA feel less pain and move better, compared with a standard hyaluronic acid treatment.
-
Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty
This study tests whether higher burden of preoperative multimorbidity affects functional recovery after knee replacement in adults with knee osteoarthritis.
-
Cartilage biomarker response to acute loading in knee OA by antiresorptive treatment status
Researchers will test whether a 30-minute treadmill walk changes cartilage biomarkers in postmenopausal women with knee osteoarthritis, comparing those on denosumab, bisphosphonates, and those not on antiresorptives.
-
Lysyl Enzymes in Knee Osteoarthritis
This study tests whether blood levels of lysyl hydroxylase and lysyl oxidase differ between people with knee osteoarthritis and healthy individuals.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.