Registry for identifying biomarkers in Takayasu's Arteritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify new biomarkers for diagnosing and monitoring disease activity in patients with Takayasu's arteritis, a rare chronic vasculitis primarily affecting young Asian women. The study will utilize various methods to analyze patient data and improve understanding of the disease mechanism, which often remains undetected until significant vascular occlusion occurs. By focusing on patients who meet specific classification criteria, the study seeks to enhance diagnostic accuracy and disease management.

Why it matters

Who can join: the full rules

Retrospective

Inclusion Criteria:

Subjects who met the American College of Rheumatology 1990 classification criteria for Takayasu arteritis:

1. Age of onset ≤40 years,
2. Claudication of upper or lower extremities,
3. Decreased pulsation of 1 or both brachial arteries,
4. Difference of ≥ 10 mmHg in systolic blood pressure between arms,
5. Bruit over subclavian arteries or aorta,
6. \*Arteriographic evidence showing a branch of the aorta stenosis or occlusion.

Meeting more than 3 of 6 criteria suggests the diagnosis of Takayasu arteritis.

\*Angiography in this study was replaced by vascular magnetic resonance angiography(MRA)or computed tomography angiography(CTA).

Exclusion Criteria:

1. Arteriographic lesions that could be entirely due to atherosclerosis,
2. Suffer from other autoimmune diseases (eg, ANCA-associated vasculitis, systemic lupus erythematosus, etc.) besides Takayasu arteritis,
3. Cogan's syndrome,
4. Behcet's disease,
5. Subjects with any serious acute or chronic infection,
6. Giant cell arteritis (large vessel vasculitis and at least 50 years old) or other infectious forms of large vessel vasculitis.

Prospective

Inclusion Criteria:

Subjects with initial suspicion of having Takayasu arteritis or patients with Takayasu arteritis need assessment of disease activity were prospectively enrolled.

Exclusion Criteria:

1. Patients without image studies.
2. Patients with confirmed other autoimmune diseases (eg, ANCA-associated vasculitis, systemic lupus erythematosus, etc.)

Where it's running

• Beijing Anzhen Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Yuan WANG, PhD
• Email: wangyuan980510@163.com
• Phone: 86-010-64456169

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Global Takayasu Arteritis Registry (GITA)

  The registry will collect past and ongoing medical information from people with Takayasu arteritis worldwide to see which treatments and patient features relate to better outcomes.

  Recruiting at 2 sites Marmara University · Istanbul, Istanbul and 1 other locations · NCT07558382

• Understanding the natural history and outcomes of systemic vasculitis

  This study is trying to understand how systemic vasculitis affects people over time and what signs can help predict how the disease will progress, involving both patients with vasculitis and healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02257866

• One-time DNA analysis for vasculitis

  This study is testing whether analyzing DNA from people with different types of vasculitis can help find genetic factors that increase the risk of these diseases and lead to better treatments.

  Recruiting at 4 sites University of Pennsylvania · Los Angeles, California and 13 other locations · NCT01241305

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.