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Registry for evaluating neurothrombectomy devices in stroke patients

Embotrap eXtraction & Clot EvaLuation & Lesion Evaluation for NeuroThrombectomy

Observational Cerenovus, Part of DePuy Synthes Products, Inc. · NCT03685578

This study is testing how well certain devices can help treat stroke patients with blocked blood vessels to see if they improve recovery and outcomes.

Quick facts

Study typeObservational
Enrollment2000 (estimated)
Ages18 Years and up
SexAll
SponsorCerenovus, Part of DePuy Synthes Products, Inc. Industry-sponsored
Locations40 sites (Birmingham, Alabama and 39 other locations)
Trial IDNCT03685578 on ClinicalTrials.gov

What this trial studies

This observational registry aims to assess the effectiveness of the CERENOVUS neurothrombectomy devices, including the EmboTrap® Revascularization Device, Large Bore Catheter/EMBOVAC Aspiration Catheter, and CEREGLIDE 71 Intermediate Catheter, in patients with acute ischemic stroke and confirmed intracranial vessel occlusion. The study will collect real-world data to explore the relationship between patient comorbidities, clot characteristics, revascularization rates, and clinical outcomes. By analyzing these factors, the registry seeks to provide insights into the performance of these devices in a clinical setting.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who are experiencing an acute ischemic stroke with confirmed intracranial vessel occlusion.

Not a fit: Patients who do not have an intracranial vessel occlusion or are not undergoing mechanical thrombectomy with the specified devices may not benefit from this study.

Why it matters

Potential benefit: If successful, this registry could enhance the understanding of neurothrombectomy devices, potentially leading to improved treatment strategies for acute ischemic stroke patients.

How similar studies have performed: Other studies evaluating neurothrombectomy devices have shown promising results, indicating that this approach is supported by prior successful research.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Age ≥ 18
2. The participant or the participant's legally authorized representative has signed and dated an Informed Consent Form. In the event that local regulations allow for alternative approaches of consent, these must be fulfilled as approved by the sponsor and site's ethics committee/regulatory authority (if applicable)
3. Participants experiencing acute ischemic stroke with angiographic confirmation of intracranial vessel occlusion
4. A clinical decision has been made to use a CERENOVUS neurothrombectomy device (EmboTrap® Revascularization Device, Large Bore Catheter/ EMBOVAC Aspiration Catheter, or CEREGLIDE 71 Intermediate Catheter) independently and prior to enrollment in the research study
5. A CERENOVUS neurothrombectomy device is the first attempted primary device/technique for mechanical thrombectomy for the intracranial occlusion in the participant. The following primary devices/techniques are eligible for this study: a) EmboTrap® Revascularization Device alone b) EmboTrap® Revascularization Device + co-aspiration with the Large Bore Catheter/EMBOVAC Aspiration Catheter or CEREGLIDE 71 Intermediate Catheter c) EmboTrap® Revascularization Device + co-aspiration with any other aspiration catheter d) Large Bore Catheter/EMBOVAC Aspiration Catheter alone (that is, direct aspiration with no stent retriever in the first attempted technique) e) CEREGLIDE 71 Intermediate Catheter alone (that is, direct aspiration with no stent retriever in the first attempted technique)

Exclusion Criteria:

1. Currently participating in an investigational (drug, device, etc) clinical trial that may confound study endpoints. Patients in observational, natural history, and/or epidemiological studies not involving intervention are eligible
2. Confirmation of positive pregnancy test according to site specific standard of care (example, test, verbal communication)
3. Use of multiple stent retrievers on the first pass

Where this trial is running

Birmingham, Alabama and 39 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Cerebral StrokeMechanical thrombectomyEmboTrapEmbovacCereglide 71
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.