Registry for early atherosclerosis in young patients
Official title: A Prospective Registry to Assess Atherosclerosis Risk Factors and Their Relationship With Coronary Plaque Properties and Genetic Variations in Patients With Early Atherosclerosis of Unclear Origin.
Run by Pauls Stradins Clinical University Hospital · NCT06393894 · Data updated 2026-11-12
This study is trying to find out how genetics and certain molecules in the blood affect the early stages of artery hardening in young people who seem healthy but have heart issues.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Pauls Stradins Clinical University Hospital Academic / other |
| Locations | 1 site (Riga) |
| Status | Recruiting |
| Started | April 1, 2019 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | May 1, 2024 |
| Trial ID | NCT06393894 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are young men under 55 and women under 65 with early atherosclerosis and coronary artery disease.
✕Probably not a fit
Patients with established risk factors such as diabetes, high cholesterol, or a significant smoking history may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational registry aims to analyze the impact of genetic variance and microRNA expression on the development of early atherosclerosis in young, apparently healthy patients with coronary artery disease. Patients undergoing coronary angiography or percutaneous transluminal coronary angioplasty at Pauls Stradins Clinical University Hospital in Latvia will be included. Blood samples will be collected for genetic analysis and microRNA expression evaluation, while near-infrared spectroscopy imaging will be utilized to assess atherosclerosis. The study seeks to identify new risk markers for early atherosclerosis to prevent serious cardiovascular complications.
Why it matters
Potential benefit: If successful, this study could lead to earlier diagnosis and prevention strategies for cardiovascular complications in young patients.
How similar studies have gone: While the approach of analyzing genetic factors in early atherosclerosis is gaining interest, this specific registry represents a novel effort in this area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Signed informed consent * Early atherosclerosis defined as coronary atherosclerosis in men aged \<55 years and women \<65 years * Coronary artery atherosclerosis with angiographically proven coronary vessel luminal stenosis ≥ 50% and ischaemia * Coronary artery atherosclerosis with planned revascularization * History of coronary artery revascularization (PTCA or coronary artery bypass surgery) * Coronary vessel suitable for NIRS pullback Exclusion criteria: * Diabetes * Total cholesterol ≥7 mmol/l and/or LDL ≥ 5 mmol/l * family hypercholesterolemia * positive family history of early cardiovascular disease (myocardial infarction, sudden cardiac death or cardiovascular disease of first degree relatives at young age - men \<55 years, women \<65 years) * malignant or resistant hypertension ≥ 10 years * body mass index ≥40 kg/m 2 ) * 20 or more pack years of smoking
Where it's running
-
Pauls Stradins Clinical University hospital
Riga, Latvia Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.