Registry for early atherosclerosis in young patients
A Prospective Registry to Assess Atherosclerosis Risk Factors and Their Relationship With Coronary Plaque Properties and Genetic Variations in Patients With Early Atherosclerosis of Unclear Origin.
Pauls Stradins Clinical University Hospital · NCT06393894
This study is trying to find out how genetics and certain molecules in the blood affect the early stages of artery hardening in young people who seem healthy but have heart issues.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Pauls Stradins Clinical University Hospital (other) |
| Locations | 1 site (Riga) |
| Trial ID | NCT06393894 on ClinicalTrials.gov |
What this trial studies
This observational registry aims to analyze the impact of genetic variance and microRNA expression on the development of early atherosclerosis in young, apparently healthy patients with coronary artery disease. Patients undergoing coronary angiography or percutaneous transluminal coronary angioplasty at Pauls Stradins Clinical University Hospital in Latvia will be included. Blood samples will be collected for genetic analysis and microRNA expression evaluation, while near-infrared spectroscopy imaging will be utilized to assess atherosclerosis. The study seeks to identify new risk markers for early atherosclerosis to prevent serious cardiovascular complications.
Who should consider this trial
Good fit: Ideal candidates are young men under 55 and women under 65 with early atherosclerosis and coronary artery disease.
Not a fit: Patients with established risk factors such as diabetes, high cholesterol, or a significant smoking history may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier diagnosis and prevention strategies for cardiovascular complications in young patients.
How similar studies have performed: While the approach of analyzing genetic factors in early atherosclerosis is gaining interest, this specific registry represents a novel effort in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Signed informed consent * Early atherosclerosis defined as coronary atherosclerosis in men aged \<55 years and women \<65 years * Coronary artery atherosclerosis with angiographically proven coronary vessel luminal stenosis ≥ 50% and ischaemia * Coronary artery atherosclerosis with planned revascularization * History of coronary artery revascularization (PTCA or coronary artery bypass surgery) * Coronary vessel suitable for NIRS pullback Exclusion criteria: * Diabetes * Total cholesterol ≥7 mmol/l and/or LDL ≥ 5 mmol/l * family hypercholesterolemia * positive family history of early cardiovascular disease (myocardial infarction, sudden cardiac death or cardiovascular disease of first degree relatives at young age - men \<55 years, women \<65 years) * malignant or resistant hypertension ≥ 10 years * body mass index ≥40 kg/m 2 ) * 20 or more pack years of smoking
Where this trial is running
Riga
- Pauls Stradins Clinical University hospital — Riga, Latvia (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Coronary Artery Disease, Atherosclerosis, Coronary, Coronary artery disease, Early atherosclerosis, MicroRNA, Near infrared spectroscopy