Registry for collecting data on periprosthetic fractures after hip and knee surgeries
Official title: Multicenter Prospective Registry for Periprosthetic Fractures After Hip or Knee Arthroplasty
Run by AO Innovation Translation Center · NCT03378557 · Data updated 2026-11-12
This study is collecting information on how different treatments for fractures around hip and knee implants affect recovery to help improve care for patients who experience these injuries.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | AO Innovation Translation Center Academic / other |
| Locations | 13 sites (Columbia, Missouri and 12 other locations) |
| Status | Recruiting |
| Started | December 31, 2018 |
| Main results expected | January 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | September 12, 2025 |
| Trial ID | NCT03378557 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older who have experienced a periprosthetic fracture after hip or knee arthroplasty requiring surgical intervention.
✕Probably not a fit
Patients who are pregnant or planning to conceive during the study period, as well as prisoners, may not benefit from this registry.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This registry aims to gather international data on the treatment of periprosthetic fractures (PPFx) following hip and knee arthroplasty. It focuses on understanding the influence of various factors such as implant types, surgical techniques, and rehabilitation programs on patient outcomes. By identifying risk factors for failure and comparing outcomes across different treatment approaches, the registry seeks to fill gaps in clinical evidence and improve future orthopedic practices. The data collected will support further research and enhance medical decision-making in the treatment of PPFx.
Why it matters
Potential benefit: If successful, this registry could lead to improved treatment strategies and better outcomes for patients with periprosthetic fractures.
How similar studies have gone: While this registry approach is not novel, it builds on previous efforts to collect data on orthopedic outcomes, which have shown promise in improving patient care.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:
* Age ≥18 years
* Post-operative PPFx after total or hemi hip or total or unicondylar knee arthroplasty (including the acetabulum, femur, patella and proximal tibia) requiring
* osteosynthesis alone or
* component revision plus plate/nail osteosynthesis
* Informed consent obtained, i.e.:
* Ability of the patient or assigned representative to understand the content of the patient information / Informed Consent Form
* Signed and dated EC / IRB approved written informed consent
* Ability to attend post-operative follow up visits
Exclusion Criteria:
* Pregnancy or women planning to conceive within the study period
* Prisoner
Where it's running
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University of Missouri Health Care
Columbia, Missouri, United States Recruiting -
Jersey City Medical Center RWJ Barnabas Health
Jersey City, New Jersey, United States Recruiting -
Saint Barnabas Medical Center Livingston
Livingston, New Jersey, United States Recruiting -
Vanderbilt University Medical Center
Nashville, Tennessee, United States Recruiting -
Universitaire Ziekenhuiven Leuven
Leuven, Belgium Recruiting -
Hospital Santa Clara
Bogotá, Colombia Recruiting
Show 7 more locations
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Charité Universitätsmedizin Berlin
Berlin, Germany Recruiting -
BG-Unfallklinik Ludwigshafen
Ludwigshafen, Germany Recruiting -
Universitätsklinikum Münster
Münster, Germany Recruiting -
Hospital Universitario Son Llàtzer
Palma de Mallorca, Spain Recruiting -
Universitätsspital Basel
Basel, Switzerland Recruiting -
Universitätsspital Zürich
Zurich, Switzerland Recruiting -
Kantonspital Baselland
Liestal, Switzerland Terminated
Study contacts
- Principal investigator: Karl Stoffel, MD — Universitätsspital Basel
- Study coordinator: Marco Minoia
- Email: marco.minoia@aofoundation.org
- Phone: +41 79 612 09 67
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Tipmed Revision Hip Prosthesis: 24-Month Post-Market Follow-Up
This PMCF study tests the safety and how well the Tipmed Revision Hip Prosthesis works in adults undergoing hip revision surgery.
-
Detecting infections in fractures around joint implants
This project will test whether routine blood tests, synovial fluid analysis, and extended joint and tissue cultures can find infections in adults who have fractures around hip or knee replacements and need surgery.
-
Analysis of fractures around implants and prosthetics in Spain
This study looks at fractures that happen around implants and prosthetics in patients across Spain to find the best ways to treat them and improve recovery.
-
Weight-Bearing CT for Healing of Periprosthetic Knee Fractures
This study tests weight-bearing CT scans to better assess healing after distal femur fractures around a knee implant in adults 50–90 years old who recently had revision knee surgery.
-
Comparing knee joint replacement to surgical fixation for elderly patients with distal femur fractures
This study is testing whether total knee joint replacement or surgical fixation works better for older patients with broken thigh bones near their knee to help them feel less pain and improve their daily activities.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.