Registry for CADASIL patients and their relatives

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the clinical spectrum and natural progression of CADASIL, a genetic disorder affecting blood vessels in the brain. It will involve a multicenter approach to assess the clinical, genetic, and epigenetic characteristics of individuals diagnosed with CADASIL, as well as asymptomatic carriers and their relatives. The goal is to enhance clinical management and understanding of the disease through comprehensive data collection and analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Sign informed consent.
2. Age\>18
3. Clinical diagnosis of patients with CADASIL,and confirmed by genetic test or skin biopsy
4. Asymptomatic NOTCH3 mutation carriers
5. Relatives of CADASIL patients or carriers
6. Unrelated healthy controls

Exclusion Criteria:

1. Unable to cooperate with inspectors
2. Serious systemic illness, such as heart, liver, kidney disease or major mental illness
3. Contraindications for imaging examination

Where it's running

• Department of Neurology , First Affiliated Hospital Fujian Medical University
  Fuzhou, Fujian, China Recruiting

Study contacts

• Study coordinator: Lin Yi, PhD
• Email: caibin929@163.com
• Phone: 13615039153

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Long-term follow-up of Korean CADASIL patients

  This 10-year project will track symptoms, brain scans, cognitive tests, and genetic data in about 500 Korean adults with CADASIL to see how the disease progresses.

  Recruiting Jeju National University Hospital · Jeju City, Jeju-do · NCT07497867

• Analyzing genetic and imaging features in CADASIL patients

  This study is trying to see how genetic and brain imaging information can help doctors better understand and treat CADASIL in patients with specific genetic markers.

  Recruiting Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Milan and 1 other locations · NCT06938100

• Establishing an Australian cohort of CADASIL patients

  This study is trying to gather information from Australian patients with CADASIL to better understand how the condition affects them over time.

  Recruiting at 4 sites The University of New South Wales · Newcastle, New South Wales and 4 other locations · NCT06148051

• Understanding the prognosis of cerebral small vessel disease

  This study looks at how different types of cerebral small vessel disease affect the health and future outcomes of patients, including issues like bleeding in the brain and memory problems.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT05734378

• Understanding CADASIL and its effects on cognitive impairment

  This study is trying to understand how CADASIL affects thinking and memory over time in people with a family history of the condition.

  Recruiting at 10 sites University of Wisconsin, Madison · Los Angeles, California and 11 other locations · NCT05677880

• Investigating genetic and non-genetic factors in small vessel disease

  This study is trying to see how genetic and non-genetic factors affect people with small vessel disease in the brain by looking at their symptoms and MRI results over two years.

  Recruiting National Taiwan University Hospital · Taipei · NCT05473637

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.