Registry for assessing the effects of Upper Tract Urothelial Cancer
Official title: A Comprehensive Prospective Assessment of the Physical and Biological Effects of Upper Tract Urothelial Cancer (UTUC)
Run by Chinese University of Hong Kong · NCT05438537 · Data updated 2026-11-12
This study is creating a registry to gather information and samples from patients with Upper Tract Urothelial Cancer to help improve understanding and treatment of the disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | November 1, 2021 |
| Main results expected | December 30, 2030 |
| Study ends | December 30, 2030 |
| Registry record updated | October 27, 2026 |
| Trial ID | NCT05438537 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include male patients over 18 years old who have UTUC and are awaiting surgery or have a history of UTUC with any prior interventions.
✕Probably not a fit
Patients who are unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to establish a comprehensive registry for patients with Upper Tract Urothelial Cancer (UTUC) at Prince of Wales Hospital in Hong Kong. It will collect clinical information, treatment outcomes, and biological samples such as blood, urine, and tumor tissue to investigate new diagnostic and therapeutic agents. The goal is to better understand the epidemiology, natural history, and management of UTUC, addressing existing controversies and limitations in treatment approaches.
Why it matters
Potential benefit: If successful, this registry could lead to improved management strategies and outcomes for patients with Upper Tract Urothelial Cancer.
How similar studies have gone: While UTUC is a less common condition, similar registries have shown promise in improving understanding and management of rare cancers, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male patients \> 18 years old * Patients who has presence of UTUC and pending for surgery * Patients who has history of UTUC with any intervention performed Exclusion Criteria: \- Patients fail to provide informed consent
Where it's running
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Prince of Wales Hospital
Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Jeremy Yuen-Chun TEOH, FRCS(Ed) MBBS — Chinese University of Hong Kong
- Study coordinator: Jeremy Yuen-Chun TEOH, FRCS(Ed)
- Email: jeremyteoh@surgery.cuhk.edu.hk
- Phone: 3505-2625
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Specimen Collection for Validation of a New urine-based bladder cancer test
This study collects urine and tumor samples from adults being evaluated or treated for urothelial cancer to validate a next‑generation sequencing platform.
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Robotic surgery for upper tract urothelial cancer patients
This study tests whether using a special robotic system for kidney and ureter surgery can safely help patients with upper tract urothelial cancer recover better and have good outcomes.
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Sequential gemcitabine plus Jelmyto for favorable high-grade upper tract urothelial cancer
This trial tests whether giving gemcitabine followed by Jelmyto directly into the kidney can control favorable high‑grade upper tract urothelial cancer and help people avoid kidney removal.
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Examining gene alterations and chemotherapy response in advanced bladder cancer
This study is testing if certain gene changes can help predict how well advanced bladder cancer patients will respond to platinum-based chemotherapy treatments.
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Urinary Cell-Free DNA Test for Urothelial Cancer Origin
This study tests a urine-based cell-free DNA test to help diagnose urothelial cancer and identify whether it started in the bladder or upper urinary tract in adults.
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Blood test for detecting tumor DNA in bladder and upper tract cancer
A blood test that looks for tumor DNA in people with muscle-invasive bladder cancer or upper tract urothelial cancer is being tested to see if it matches what’s found in tumor tissue and if it can help track recurrence or remission over two years.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.