Registry for adults and children with morphea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Morphea in Adults and Children (MAC) cohort is the first registry dedicated to understanding morphea, a form of localized scleroderma, in both adults and children. This observational study aims to track the progression of morphea over time, identify associated complications such as arthritis, and explore the potential autoimmune nature of the condition. Participants will be monitored to gather valuable data that can enhance understanding and treatment of morphea. The study includes patients aged 0 to 90 years with a confirmed diagnosis of morphea.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient must have a clinical diagnosis of morphea confirmed by the primary investigator and by histopathological examination.
2. Ages 0-90 years old
3. Children must weigh more than 20 lbs. in order to satisfy Children's Medical Center policy for the maximum amount of blood drawn in a 24 hour period.
4. Patient or legal guardian must be able to speak and read at a 6th grade reading level.
5. Both male and female patients will be eligible
6. All races and ethnic backgrounds will be included
7. Relationships to proband: All patients with morphea will be included. A patient's family history will be reviewed and if there is a family history of morphea or systemic sclerosis then we will give the study patient the investigator's contact information and ask the family member to call the study team to answer any questions and enroll them in the study if they choose to do so.
8. Ability to give informed consent: Patients must be able to give informed consent or they will give assent with parent or guardian consent as a minor to be a part of the morphea registry.

Exclusion Criteria:

\- Patients who have been coded as morphea (701.0), but do not have morphea/localized scleroderma (examples: steroid atrophy, acquired keratoderma, keloids, nephrogenic fibrosing dermopathy, systemic sclerosis, lichen sclerosis)

Where it's running

• UT Southwestern Medical Center - Department of Dermatology
  Dallas, Texas, United States Recruiting

Study contacts

• Principal investigator: Heidi Jacobe, MD, MSCS — University of Texas Southwestern Medical Center
• Study coordinator: Heidi Jacobe, MD, MSCS
• Email: heidi.jacobe@utsouthwestern.edu
• Phone: 214.633.1837

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Biopsychosocial (BETY) exercise program for children and adults with scleroderma

  This project will test whether BETY, a biopsychosocial exercise program, helps children and adults with scleroderma improve physical function and psychosocial well-being.

  Recruiting Hacettepe University · Ankara, Altındağ · NCT07292961

• Physical performance and daily function in people with scleroderma

  This project will test which questionnaires and simple physical tests best measure physical performance and daily functioning in children and adults with scleroderma.

  Recruiting Hacettepe University · Çankaya, Ankara · NCT07183072

• Chewing and swallowing performance in people with scleroderma

  This project will see how children and adults with scleroderma chew and swallow and collect biopsychosocial information using questionnaires.

  Recruiting Hacettepe University · Çankaya, Ankara · NCT07182981

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.