Regional nerve blocks for anterior-approach hip replacement (SIFI vs ESP)
OPPOSED (anteriOr hiP arthroPlasty regiOnal aneSthEsia stuDy) Study. Regional Anesthesia Techniques for Anterior Approach Hip Arthroplasty Analgesia: SIFI Block Versus Lumbar ESP Block
This trial will test whether adding a supra-inguinal fascia iliaca (SIFI) block or an erector spinae plane (ESP) block can reduce early pain and opioid side effects after elective anterior approach total hip replacement in adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | A.O.U. Città della Salute e della Scienza Academic / other |
| Locations | 1 site (Torino, TO) |
| Trial ID | NCT07017192 on ClinicalTrials.gov |
What this trial studies
This is a single-center interventional study enrolling adults having elective unilateral total hip arthroplasty via the direct anterior approach who can give informed consent. Participants will receive one of two regional anesthesia techniques (SIFI block or ESP block) in addition to standard perioperative care. The trial will track early postoperative pain (with attention to the first 12 hours), opioid consumption, and opioid-related side effects such as nausea and vomiting, as well as measures of early mobilization and recovery. Procedures and outcomes are measured at the treating hospital in Turin, Italy.
Who should consider this trial
Good fit: Adults aged 18–85 scheduled for elective unilateral total hip arthroplasty using the direct anterior approach who can understand the study and give informed consent are ideal candidates.
Not a fit: Patients having revision or bilateral hip surgeries, urgent/emergent operations, those with cognitive impairment, pregnancy, or known allergy to study drugs are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the approach could provide better early pain control, lower opioid needs, fewer opioid side effects, and faster initial recovery after anterior hip replacement.
How similar studies have performed: Prior research on regional blocks for hip arthroplasty has generally shown reduced pain and opioid use, but direct comparisons of supra-inguinal fascia iliaca versus erector spinae plane blocks for anterior approach THA remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>=18 years and =\<85 years * patients undergoing elective unilateral THA with direct anterior approach * patients able to understand the purposes of the study and provide signed informed consent Exclusion Criteria: * pregnancy * Age \<18 years or \>85 years * revision or bilateral surgeries * psychiatric pathology or cognitive deficits, mental retardation, inability to provide valid informed consent * History of illicit drugs and/or alcohol abuse * urgent/emergent surgery with admission to Intensive Care under sedation and mechanical ventilation or complications that do not allow evaluation * known allergy to the drugs used in the study * refusal to provide informed consent
Where this trial is running
Torino, TO
- AOU Città della Salute e della Scienza — Torino, To, Italy (Recruiting)
Study contacts
- Study coordinator: Marco Ulla, MD
- Email: marco.ulla@gmail.com
- Phone: 0039-3397548673
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.