Regional nerve blocks for anterior-approach hip replacement (SIFI vs ESP)
Official title: OPPOSED (anteriOr hiP arthroPlasty regiOnal aneSthEsia stuDy) Study. Regional Anesthesia Techniques for Anterior Approach Hip Arthroplasty Analgesia: SIFI Block Versus Lumbar ESP Block
Run by A.O.U. Città della Salute e della Scienza · NCT07017192 · Data updated 2026-11-12
This trial will test whether adding a supra-inguinal fascia iliaca (SIFI) block or an erector spinae plane (ESP) block can reduce early pain and opioid side effects after elective anterior approach total hip replacement in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | A.O.U. Città della Salute e della Scienza Academic / other |
| Locations | 1 site (Torino, TO) |
| Status | Recruiting |
| Started | June 23, 2025 |
| Main results expected | October 23, 2026 |
| Study ends | December 23, 2026 |
| Registry record updated | August 27, 2026 |
| Trial ID | NCT07017192 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–85 scheduled for elective unilateral total hip arthroplasty using the direct anterior approach who can understand the study and give informed consent are ideal candidates.
✕Probably not a fit
Patients having revision or bilateral hip surgeries, urgent/emergent operations, those with cognitive impairment, pregnancy, or known allergy to study drugs are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center interventional study enrolling adults having elective unilateral total hip arthroplasty via the direct anterior approach who can give informed consent. Participants will receive one of two regional anesthesia techniques (SIFI block or ESP block) in addition to standard perioperative care. The trial will track early postoperative pain (with attention to the first 12 hours), opioid consumption, and opioid-related side effects such as nausea and vomiting, as well as measures of early mobilization and recovery. Procedures and outcomes are measured at the treating hospital in Turin, Italy.
Why it matters
Potential benefit: If successful, the approach could provide better early pain control, lower opioid needs, fewer opioid side effects, and faster initial recovery after anterior hip replacement.
How similar studies have gone: Prior research on regional blocks for hip arthroplasty has generally shown reduced pain and opioid use, but direct comparisons of supra-inguinal fascia iliaca versus erector spinae plane blocks for anterior approach THA remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>=18 years and =\<85 years * patients undergoing elective unilateral THA with direct anterior approach * patients able to understand the purposes of the study and provide signed informed consent Exclusion Criteria: * pregnancy * Age \<18 years or \>85 years * revision or bilateral surgeries * psychiatric pathology or cognitive deficits, mental retardation, inability to provide valid informed consent * History of illicit drugs and/or alcohol abuse * urgent/emergent surgery with admission to Intensive Care under sedation and mechanical ventilation or complications that do not allow evaluation * known allergy to the drugs used in the study * refusal to provide informed consent
Where it's running
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AOU Città della Salute e della Scienza
Torino, To, Italy Recruiting
Study contacts
- Study coordinator: Marco Ulla, MD
- Email: marco.ulla@gmail.com
- Phone: 0039-3397548673
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.