Reducing tooth sensitivity with different toothpaste

Reduction of Dentine Hypersensitivity After Non-surgical Periodontal Therapy Comparing 5% Calcium Sodium Phosphosilicate and 8% Arginine Dentifrices: a Single Centre, Randomized Control Trial

This study is testing two types of toothpaste to see if they can help people with gum disease and tooth sensitivity feel better after dental treatment.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 87 (estimated)
• Ages: 30 Years to 65 Years
• Sex: All
• Sponsor: Armed Forces Institute of Dentistry, Pakistan (Academic / other)
• Locations: 1 site (Rawalpindi)
• Trial ID: NCT06273930 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of two types of dentifrices, 5% Calcium Sodium Phosphosilicate and 8% Arginine, in reducing dentinal hypersensitivity in patients with periodontitis after non-surgical periodontal therapy. Participants aged 30 to 65 years with moderate to severe sensitivity will be selected based on specific inclusion and exclusion criteria. The study will utilize descriptive statistics to analyze the impact of these treatments on sensitivity levels following dental procedures.

Who should consider this trial

Good fit: Ideal candidates are adults aged 30 to 65 with generalized chronic periodontitis and moderate to severe dentinal hypersensitivity.

Not a fit: Patients with hypersensitivity due to dental caries or other dental issues unrelated to periodontal treatment may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide effective treatment options for patients suffering from dentinal hypersensitivity.

How similar studies have performed: Previous studies have shown varying degrees of success with similar dentifrice approaches, but this specific comparison is novel.

Eligibility criteria

Inclusion Criteria:

1. Participants must be between 30 and 65 years old.
2. Participants should be in good general health.
3. Participants must have a diagnosis of generalized chronic periodontitis according to the 1999 classification definition.
4. Participants should complain of at least two teeth with dentinal hypersensitivity.
5. Participants must exhibit moderate to severe dentinal hypersensitivity (Schiff's scores of 2 to 3) or tactile stimulation (Visual Analogue Scale (VAS) score \>4) after at least one scaling and root planing session.

Exclusion Criteria:

1. Individuals with dentinal hypersensitivity symptoms prior to periodontal treatment.
2. Those who have used agents to treat hypersensitivity in the past 3 months.
3. Participants who are allergic to the test products (5% CSPS or 8% arginine).
4. Dentinal hypersensitivity caused by factors such as dental caries, defective restorations, fractured teeth, abrasion or abfraction, extensively restored teeth, or restorations extending into the test area.
5. Individuals who have undergone orthodontic treatment within the past 3 months.
6. Patients with crowded teeth or serving as abutment teeth for fixed or removable prostheses are also excluded from the study.

Where this trial is running

Rawalpindi

• Afid — Rawalpindi, Pakistan (Recruiting)

Study contacts

• Principal investigator: Muhammad J Iqbal — Afid
• Study coordinator: Muhammad J Iqbal, BDS

Conditions Sensitivity, Tooth