Reducing the spread of antibiotic-resistant infections from hospitals to communities
Interventions to Decrease Carbapenem Resistant Enterobacteriaceae Colonization and Transmission Between Hospitals, Households, Communities and Domesticated Animals
This study is testing a set of strategies to see if they can help stop the spread of antibiotic-resistant infections from hospitals to families and communities.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 800 (estimated) |
| Ages | N/A to 24 Months |
| Sex | All |
| Sponsor | Hanoi University of Public Health Academic / other |
| Locations | 1 site (Thái Bình, Thai Binh) |
| Trial ID | NCT05871476 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to assess the effectiveness of a bundle of interventions designed to reduce the transmission of Carbapenem-resistant Enterobacteriaceae (CRE) from hospitalized patients to their households and communities. The study will involve a cluster randomized controlled trial where districts in two provinces will be assigned to either an intervention or control group. Interventions include education on hygiene practices, communication strategies, and reducing antibiotic use, developed in collaboration with local health authorities. The impact of these interventions will be evaluated through screening for CRE in household members, livestock, and the environment, alongside surveys to assess knowledge and practices related to health and hygiene.
Who should consider this trial
Good fit: Ideal candidates for this study are patients under 2 years old who are discharged from the selected hospital.
Not a fit: Patients not from the selected hospital or those outside the selected province may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce the transmission of antibiotic-resistant infections, improving public health outcomes.
How similar studies have performed: Other studies have shown success with similar interventions aimed at reducing antibiotic resistance transmission, indicating a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients under 2 years old at the selected hospital are highly appreciated to join the study. Exclusion Criteria: * Patients not from the selected hospital and individuals outside the selected province
Where this trial is running
Thái Bình, Thai Binh
- Thai Binh Pediatric Hospital — Thái Bình, Thai Binh, Vietnam (Recruiting)
Study contacts
- Principal investigator: Mattias Larsson, MD — Karolinska Institutet
- Study coordinator: Phuc Pham-Duc, MD, PhD
- Email: pdp@huph.edu.vn
- Phone: 84904049969
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.