Reducing infections after total joint replacement surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of using antiseptic solutions and direct antibiotic application to reduce the risk of periprosthetic joint infections in patients undergoing total joint replacements. Participants will be randomized to receive either standard care or the experimental interventions, which include chlorhexidine gluconate, vancomycin hydrochloride, and povidone-iodine. The study focuses on patients aged 18 and older who are undergoing primary or aseptic revision total joint replacement. By comparing infection rates between the two groups, the trial seeks to determine if these interventions can lower the incidence of infections that lead to reoperations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients 18 years of age or older.
2. Undergoing primary or aseptic revision TJR.
3. No contraindications to study interventions.
4. Informed consent (participant or substitute decision maker) obtained and willing to comply with the protocol.

Exclusion Criteria:

1. Received antibiotics for any reason in the two weeks prior to their TJR.
2. Chronic or acute infection at or near the TJR site.
3. Prior history of periprosthetic joint infection including any reoperation due to infection.
4. Undergoing surgery for a diagnosis of a fracture.
5. Open infected wounds on affected limb.
6. Undergoing bilateral TJR.
7. Currently enrolled in a study that does not permit co-enrollment.
8. Prior enrollment in the trial including the pilot study
9. Any condition or circumstance, which in the opinion of the Investigator, interferes with assessments or completion of the trial.

Where it's running

• Hamilton Health Sciences - Juravinski Hospital and Cancer Centre
  Hamilton, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Thomas J Wood, MD, FRCSC — Hamilton Health Sciences / McMaster University
• Study coordinator: Lindsay Maharaj, MSc
• Email: maharajli@hhsc.ca
• Phone: 905-521-2100

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating antibiotic treatment after joint revision surgery for infection

  This study is testing if a specific antibiotic treatment after joint revision surgery for infection can help patients recover better and prevent further infections.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.