Reducing fatigue in people with multiple sclerosis using TENS treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, sham-controlled trial aims to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) in reducing fatigue levels in individuals with multiple sclerosis (MS). Participants aged 18-65 will be randomly assigned to receive either an effective dose of TENS or a sham treatment over 18 sessions across 6 weeks. The study will measure changes in self-reported fatigue and fatigability before, during, and after the intervention. The ultimate goal is to develop strategies to lessen the impact of fatigue on daily activities for those living with MS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women18-65 yrs
* Able to read, understand, and speak English to ensure safe participation in the project
* Clinical diagnosis of relapsing-remitting MS
* Self-reported difficulty with walking
* On stable doses of Ampyra, provigil, or other symptomatic-treating medications
* No relapse or systemic steroids within the last 30 days
* Able to arrange transportation to the Boulder campus

Exclusion Criteria:

* Vision or hearing problems that have not been corrected
* Problems with sensations to temperature, pressure, or pain
* Any arm or leg problems that would influence the ability to hold a weight
* Surgery to the arms or legs that continues to bother the participant
* Metal implants
* Medical diagnosis or condition that is considered to be an absolute or relative contraindication to participating in exercise training, such as major renal, pulmonary, hepatic, cardiac, gastrointestinal, HIV, cancer (other than treated basal cell cancer), other neurological disorders, or pregnancy
* History of head injury or stroke
* Taking antidepressants, anticholinergics, stimulants, sedatives, cannabis, illicit drugs or medications to treat herpes or neurologic pain.
* Diagnosis of diabetes mellitus
* Poorly controlled hypertension
* History of seizure disorders
* ≥2 alcoholic drinks/day, or present history (last 6 months) of drug abuse
* Spasticity that requires the individual to change intended activities more often than once a week
* Skin diseases or sensation problems in the legs or hands that influences some activities more often than once a week
* Inability to attend exercise sessions 3 days per week for 6 weeks

Where it's running

• University of Colorado
  Boulder, Colorado, United States Recruiting

Study contacts

• Study coordinator: Roger Enoka, PhD
• Email: enoka@colorado.edu
• Phone: 3034927232

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.