Reducing dental sensitivity during at-home teeth whitening with carbamide peroxide
Efficacy in the Reduction of Hypersensitivity During Home Whitening With 16% Carbamide Peroxide Applied on Alternate Days: a Randomized Clinical Trial
This study tests if using a teeth whitening gel every day or every other day helps people with sensitive teeth feel better while whitening their smiles.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universidad Rey Juan Carlos Academic / other |
| Locations | 1 site (Alcorcón, Madrid) |
| Trial ID | NCT06035588 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a 16% carbamide peroxide whitening treatment applied either daily or every other day over three weeks. Participants will use the whitening gel for two hours each day, and their dental sensitivity and satisfaction will be assessed throughout the treatment period. The study aims to determine if the frequency of application affects the level of dental hypersensitivity experienced by patients. Color changes in teeth will be measured using both subjective and objective methods at various intervals.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with vital teeth that have not undergone previous whitening treatments and are in good oral health.
Not a fit: Patients with a history of dental sensitivity, those undergoing orthodontic treatment, or individuals with certain dental conditions will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help patients achieve whiter teeth with reduced sensitivity during at-home whitening treatments.
How similar studies have performed: Previous studies have shown varying degrees of success with similar whitening approaches, but this specific concentration and application frequency is less commonly tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients older than 18 years. * Patients with vital teeth without restorations, single crowns, implants and/or bridges at the level of the anterior teeth. * Absence of cavities in the teeth to be whitened. * Patients with satisfactory oral hygiene and periodontally healthy, who are not undergoing periodontal maintenance and who do not use chlorhexidine mouthwashes. Patients with recessions without presenting sensitivity will be included. * Absence of sensitivity, measured with the application of air with the dental team's syringe. * Patients whose canines have at least an A2-A3 shade (VITA Classic® Guide). Exclusion Criteria: * Patients who have previously undergone whitening (less than 5 years). * Patients undergoing orthodontic treatment. * Patients with white spots or alterations in the development of enamel or with stains. * Patients with a history of trauma to anterior teeth. * Patients who require internal whitening. * Smokers. * Pregnant or lactating. * Patients with allergies to any whitening component. * Patients presenting alterations of the oral mucosa (desquamative gingivitis, oral lichen planus, leukoplakia, etc.). * Patients with medical conditions considered by the researchers that may compromise the study or the individual safety of the patient. * Patients with poor oral hygiene. * Patients with previous hypersensitivity.
Where this trial is running
Alcorcón, Madrid
- Isabel Giraldez de Luis — Alcorcón, Madrid, Spain (Recruiting)
Study contacts
- Study coordinator: ISABEL GIRALDEZ DE LUIS, Lecturer
- Email: isabel.giraldez@urjc.es
- Phone: 669119781
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.