Reducing cockroach allergens to improve asthma in children
Comparative Effectiveness of Multi Versus Single Intervention Allergen Reduction Strategies on Asthma Morbidity
This study is testing two different ways to reduce cockroach allergens in homes to see if it helps children with asthma feel better and have fewer symptoms.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 290 (estimated) |
| Ages | 5 Years to 17 Years |
| Sex | All |
| Sponsor | Tulane University Academic / other |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (New Orleans, Louisiana) |
| Trial ID | NCT04331353 on ClinicalTrials.gov |
What this trial studies
The Allergen Reduction and Child Health Study (ARCHS) is a 12-month randomized control trial aimed at improving asthma outcomes in children aged 5 to 17 who are exposed to cockroaches. The study recruits participants from the Greater New Orleans area and compares the effectiveness of a simple insecticidal bait intervention against a more complex multicomponent approach to reduce asthma triggers. The primary focus is on reducing cockroach exposure in the home, which is a significant allergen for many children with asthma. The study aims to assess the impact of these interventions on asthma symptoms, healthcare utilization, and overall quality of life.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 5 to 17 with uncontrolled persistent asthma who have documented exposure to cockroaches.
Not a fit: Patients with other serious medical conditions or chronic illnesses that require daily medication may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved asthma control and quality of life for children suffering from asthma triggered by cockroach allergens.
How similar studies have performed: Previous studies have shown success in reducing asthma symptoms through allergen reduction strategies, making this approach promising yet still requiring further investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 5 - 17 years; with uncontrolled persistent asthma defined as the child experiencing at least one of the following: one overnight hospitalization for asthma within the past six months OR two unscheduled clinic or emergency department visits for asthma within the last 12 months; and either on a long term controller medication for asthma, or have asthma symptoms 3 or more days per week over the past 2 weeks or nighttime asthma symptoms at least 3 times in the past month exposure to cockroach - defined as trapping at least one cockroach in a 3 day period OR visual evidence of cockroaches by field staff; and the child must sleep in the target home at least 4 nights per week on average. Caregiver ability to speak English or Spanish. Exclusion Criteria: * Other serious medical or chronic illnesses including chronic respiratory infections that require daily medication, cardiovascular disease that requires daily medication, excluding hypertension, taking a beta-blocker, a current active smoker, currently receiving immunotherapy or plans to move within the 12 month follow-up.
Where this trial is running
New Orleans, Louisiana
- Tulane University — New Orleans, Louisiana, United States (Recruiting)
Study contacts
- Principal investigator: Felicia Rabito, PhD — Tulane University School of Public Health and Tropical Medicine
- Study coordinator: Derek Werthmann, PhD
- Email: dwrthma@tulane.edu
- Phone: 5049882386
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.