Reducing Blood Pressure Variability to Decrease Postoperative Nausea and Vomiting
The Effect of Minimizing Blood Pressure Variability on Postoperative Nausea and Vomiting in Women Undergoing Non-cardiac Surgery With Minor to Moderate Risk - a Prospective Randomized Clinical Trial
This study tests if managing blood pressure more closely during surgery can help women avoid nausea and vomiting after their operation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 272 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna) |
| Trial ID | NCT05596695 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the relationship between intraoperative blood pressure variability and the incidence of postoperative nausea and vomiting (PONV) in women undergoing elective minor to moderate risk non-cardiac surgery. The study will randomly assign participants to either a group receiving targeted blood pressure management or standard care. The primary outcome will be the incidence of PONV during the first two hours post-surgery, assessed using a visual analog scale. By minimizing blood pressure variability, the trial aims to provide insights into improving postoperative recovery outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18 to 50 scheduled for elective minor to moderate risk non-cardiac surgery.
Not a fit: Patients undergoing emergency surgery or those with specific medical conditions such as pregnancy or vestibular dysfunction may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative nausea and vomiting in patients undergoing surgery.
How similar studies have performed: While limited data exists on this specific approach, the relationship between blood pressure management and postoperative outcomes has been explored in other studies, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women 18-50 years of age at time of surgery * ASA physical status I and II * Scheduled for elective minor or moderate risk non-cardiac surgery with expected time of surgery ≥1 hour Exclusion Criteria: * Patients undergoing emergency surgery * Scheduled for pheochromocytoma surgery * Nausea and/or vomiting on the morning before surgery * Taking anti-emetic drugs * Pregnancy * Dysfunction of the vestibular system
Where this trial is running
Vienna
- Medical University of Vienna — Vienna, Austria (Recruiting)
Study contacts
- Principal investigator: Christian Reiterer, MD — Medical University of Vienna
- Study coordinator: Katharina Horvath, MD
- Email: katharina.horvath@meduniwien.ac.at
- Phone: 0043 1 40400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.