Reduced frequency of pembrolizumab treatment for advanced lung cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the safety and effectiveness of reducing the frequency of pembrolizumab treatment in patients with advanced non-small cell lung cancer (NSCLC) who have been progression-free after 6 months of standard therapy. Participants will be randomized to receive either the standard 6-week treatment or a reduced frequency of 12 weeks, with further arms testing 9, 15, and 18 weeks if initial results are promising. The goal is to determine if less frequent dosing can maintain efficacy while reducing treatment burden and costs. The study aims to enhance patient quality of life by minimizing hospital visits and potential side effects associated with more frequent treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent prior to initiation of any study procedures and willingness and ability to comply with the study schedule
* Any patient ≥18yrs who has received 6 months of pembrolizumab treatment with or without chemotherapy for advanced Non small cell lung cancer who is planned to continue immunotherapy treatment because of continued benefit.

Exclusion Criteria:

* Disease progression or not tolerating treatment at 6 months into therapy
* Clinician does not intend to continue immunotherapy
* Any patient with a synchronous primary cancer. This includes any new cancer diagnoses or relapse of previously treated cancer since starting pembrolizumab treatment.
* Any patient currently receiving an investigational agent and/or using an investigational device or has participated in a study of an investigational agent and/or used an investigational device within 28 days of randomisation.

Where it's running

• Royal Bournemouth Hospital
  Bournemouth, United Kingdom Recruiting
• Royal Sussex County Hospital
  Brighton, United Kingdom Recruiting
• Bristol Haematology and Oncology Centre
  Bristol, United Kingdom Recruiting
• Queen's Hospital
  Burton-on-Trent, United Kingdom Recruiting
• East Kent Hospitals University NHS Foundation Trust
  Canterbury, United Kingdom Recruiting
• Velindre Cancer Centre
  Cardiff, United Kingdom Recruiting

Study contacts

• Principal investigator: Michael Seckl — Imperial College London
• Study coordinator: Alex Baker
• Email: a.williams@imperial.ac.uk
• Phone: 020 7594 2180

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.